Optimization of Carboxymethyl-Xyloglucan-Based Tramadol Matrix Tablets Using Simplex Centroid Mixture Design
Table 4
Composition of to formulations.
Ingredients
Formulations (mg)
Tramadol HCl
100
100
100
100
100
100
100
Carboxymethyl xyloglucan
200
180
180
190
190
180
186.67
HPMC-k-100M
10
30
10
20
10
20
16.67
DCP
30
30
50
30
40
40
36.67
Talc
5
5
5
5
5
5
5
Magnesium stearate
5
5
5
5
5
5
5
PVP K-30
30
30
30
30
30
30
30
Isopropyl alcohol
qs.
qs.
qs.
qs.
qs.
qs.
qs.
Total
380
380
380
380
380
380
380
All quantities in mg.
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