/ / / Tab 6

Research Article

Optimization of Carboxymethyl-Xyloglucan-Based Tramadol Matrix Tablets Using Simplex Centroid Mixture Design

Table 6

Pre- and postcompression properties of optimization batches .


Parameters

Bulk density (g/mL)	0.387 ± 0.22	0.355 ± 0.17	0.303 ± 0.11	0.409 ± 0.30	0.343 ± 0.11	0.318 ± 0.16	0.366 ± 0.15
Tapped density (g/mL)	0.442 ± 0.14	0.416 ± 0.35	0.426 ± 0.03	0.493 ± 0.26	0.428 ± 0.05	0.374 ± 0.04	0.412 ± 0.04
Angle of repose	27.78 ± 0.14	26.05 ± 0.08	25.55 ± 0.12	29.85 ± 0.02	28.08 ± 0.16	27.08 ± 0.08	26.06 ± 0.04
Carr’s index	13.44 ± 0.14	12.66 ± 0.11	12.3 ± 0.16	14.43 ± 0.13	14.06 ± 0.12	13.97 ± 0.17	12.17 ± 0.15
Hausner’s ratio	1.14 ± 0.18	1.17 ± 0.28	1.41 ± 0.07	1.21 ± 0.28	1.24 ± 0.08	1.17 ± 0.13	1.13 ± 0.11
Hardness (kg/cm²)	5.1 ± 0.33	5.3 ± 0.26	5.5 ± 0.18	5.4 ± 0.34	5.7 ± 0.17	5.5 ± 0.32	5.4 ± 0.13
Friability	0.74 ± 0.21	0.70 ± 0.11	0.57 ± 0.22	0.62 ± 0.16	0.42 ± 0.12	0.52 ± 0.23	0.67 ± 0.22
Uniformity of weight (mg)	378.29 ± 0.34	379.78 ± 0.45	378.98 ± 0.55	381.19 ± 0.36	382.4 ± 0.12	378.56 ± 0.24	381.78 ± 0.13
Drug content (%)	100.22 ± 0.22	100.62 ± 0.11	99.14 ± 0.18	98.34 ± 0.39	98.72 ± 0.21	101.16 ± 0.67	98.52 ± 0.89
Thickness (mm)	4.40 ± 0.014	4.17 ± 0.016	3.89 ± 0.026	4.29 ± 0.016	4.02 ± 0.031	4.22 ± 0.014	3.83 ± 0.034

±SD (standard deviation) .

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