Journal of Pharmaceutics / 2013 / Article / Tab 6

Research Article

Optimization of Carboxymethyl-Xyloglucan-Based Tramadol Matrix Tablets Using Simplex Centroid Mixture Design

Table 6

Pre- and postcompression properties of optimization batches .

Parameters

Bulk density (g/mL)0.387 ± 0.22 0.355 ± 0.17 0.303 ± 0.11 0.409 ± 0.30 0.343 ± 0.11 0.318 ± 0.16 0.366 ± 0.15
Tapped density (g/mL)0.442 ± 0.14 0.416 ± 0.35 0.426 ± 0.03 0.493 ± 0.26 0.428 ± 0.05 0.374 ± 0.04 0.412 ± 0.04
Angle of repose27.78 ± 0.14 26.05 ± 0.08 25.55 ± 0.12 29.85 ± 0.02 28.08 ± 0.16 27.08 ± 0.08 26.06 ± 0.04
Carr’s index13.44 ± 0.14 12.66 ± 0.11 12.3 ± 0.16 14.43 ± 0.13 14.06 ± 0.12 13.97 ± 0.17 12.17 ± 0.15
Hausner’s ratio1.14 ± 0.18 1.17 ± 0.28 1.41 ± 0.07 1.21 ± 0.28 1.24 ± 0.08 1.17 ± 0.13 1.13 ± 0.11
Hardness (kg/cm2)5.1 ± 0.33 5.3 ± 0.26 5.5 ± 0.18 5.4 ± 0.34 5.7 ± 0.17 5.5 ± 0.32 5.4 ± 0.13
Friability0.74 ± 0.21 0.70 ± 0.11 0.57 ± 0.22 0.62 ± 0.16 0.42 ± 0.12 0.52 ± 0.23 0.67 ± 0.22
Uniformity of weight (mg) 378.29 ± 0.34 379.78 ± 0.45 378.98 ± 0.55 381.19 ± 0.36 382.4 ±
0.12
378.56 ± 0.24 381.78 ± 0.13
Drug content (%)100.22 ± 0.22 100.62 ± 0.11 99.14 ± 0.18 98.34 ± 0.39 98.72 ± 0.21 101.16 ± 0.67 98.52 ± 0.89
Thickness (mm)4.40 ± 0.014 4.17 ± 0.016 3.89 ± 0.026 4.29 ± 0.016 4.02 ± 0.031 4.22 ± 0.014 3.83 ± 0.034

±SD (standard deviation) .

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