Research Article
Optimization of Carboxymethyl-Xyloglucan-Based Tramadol Matrix Tablets Using Simplex Centroid Mixture Design
Table 7
Composition of optimum formulations
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, and
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| | Composition (mg) | Formulations | | | |
| | Tramadol HCl | 100 | 100 | 100 | | Carboxymethyl xyloglucan | 194.39 | 190.606 | 200 | | HPMC-K-100M | 15.610 | 19.394 | 10 | | DCP | 30 | 30 | 30 | | Talc | 5 | 5 | 5 | |
Magnesium stearate | 5 | 5 | 5 | | PVP K-30 | 30 | 30 | 30 | | Isopropyl alcohol | qs. | qs. | qs. |
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