Simultaneous Determination of Clidinium Bromide and Chlordiazepoxide in Combined Dosage Forms by High-Performance Liquid Chromatography
Table 2
Sensitivity and regression parameters.
Parameter
Clidinium bromide
Chlordiazepoxide
Optimum concentration range (g mL−1)
2.5–300.0
3.0–500.0
Regression equation*
Correlation coefficient ()
0.9999
0.9999
Standard deviation of slope
0.0019
0.0025
Standard deviation of intercept
0.0135
0.0504
Regression equation**
Correlation coefficient ()
0.9999
0.9999
Standard deviation of slope
1.1 × 10−5
2.8 × 10−5
Standard deviation of intercept
5.9 × 10−4
8.1 × 10−4
Limit of quantification, LOQ (g mL−1)
0.294
0.403
Limit of detection, LOD (g mL−1)
0.088
0.121
Regression equation for the peak area of drug versus concentration of drug in g mL−1.
**Regression equation for the ratio of peak area of drug to that of I.S. versus concentration of drug in g mL−1.
