Simultaneous Determination of Clidinium Bromide and Chlordiazepoxide in Combined Dosage Forms by High-Performance Liquid Chromatography

Table 2

Sensitivity and regression parameters.

Parameter

Clidinium bromide

Chlordiazepoxide

Optimum concentration range (g mL^{−1})

2.5–300.0

3.0–500.0

Regression equation*

Correlation coefficient ()

0.9999

0.9999

Standard deviation of slope

0.0019

0.0025

Standard deviation of intercept

0.0135

0.0504

Regression equation**

Correlation coefficient ()

0.9999

0.9999

Standard deviation of slope

1.1 × 10^{−5}

2.8 × 10^{−5}

Standard deviation of intercept

5.9 × 10^{−4}

8.1 × 10^{−4}

Limit of quantification, LOQ (g mL^{−1})

0.294

0.403

Limit of detection, LOD (g mL^{−1})

0.088

0.121

Regression equation for the peak area of drug versus concentration of drug in g mL^{−1}.
**Regression equation for the ratio of peak area of drug to that of I.S. versus concentration of drug in g mL^{−1}.