Simultaneous Determination of Clidinium Bromide and Chlordiazepoxide in Combined Dosage Forms by High-Performance Liquid Chromatography

Table 6

Determination of CDB and CDZ in pharmaceutical formulations by the proposed method and official method.

Sample	Clidinium bromide		Chlordiazepoxide
	% Recovery^a  ±  S.D.
	Proposed method	Official method	Proposed method	Official method
Ribax (2.5 mg CDB and 5.0 mg CDZ/capsule)
X ± S.D.^a	100.49±1.92	100.97±1.58	100.89±0.22	100.04±0.17
t-value^b	1.96	2.03	2.12	1.89
F-value^b	1.47		1.67
Laberax (2.5 mg CDB and 5.0 mg CDZ/tablet)
X ± S.D.^a	102.58±0.51	101.33±0.42	100.59±0.30	99.85±0.23
t-value^b	1.28	1.92	1.73	1.83
F-value^b	1.47		1.70
Librax (2.5 mg CDB and 5.0 mg CDZ/tablet)
X ± S.D.^a	103.45±1.17	102.06±1.08	100.25±0.31	100.12±0.28
t-value^b	2.04	2.18	1.60	1.74
F-value^b	1.17		1.23

^aFive independent analyses.
^bTheoretical values for 𝑡 and F-values at five degree of freedom and 95% confidence limit are (𝑡=2.776) and (𝐹=6.26).