Solubility Enhancement of Raloxifene Using Inclusion Complexes and Cogrinding Method

Table 4

Solubility of RLX and cogrind mixtures in different solvent at 37 ± 0.5°C after 48 hrs. All values are mean ± S.D, 𝑛 = 3.

Sample	Medium
	Water; (mg/mL)	pH 1.2 HCl buffer; (mg/mL)	pH 7 phosphate buffer; (mg/mL)
RLX	0.097 ± 0.105	0.082 ± 0.079	0.076 ± 0.023
RLX-GG	2.090 ± 0.002*	2.037 ± 0.160*	2.610 ± 0.020*
RLX-MGG	3.570 ± 0.27*	3.173 ± 0.030*	3.870 ± 0.360*

*Significant (𝑃 value < 0.05).