Journal of Pharmaceutics / 2013 / Article / Tab 4

Research Article

Solubility Enhancement of Raloxifene Using Inclusion Complexes and Cogrinding Method

Table 4

Solubility of RLX and cogrind mixtures in different solvent at 37 ± 0.5°C after 48 hrs. All values are mean ± S.D, = 3.

SampleMedium
Water
(mg/mL)
pH 1.2 HCl buffer
(mg/mL)
pH 7 phosphate buffer
(mg/mL)

RLX0.097 ± 0.1050.082 ± 0.0790.076 ± 0.023
RLX-GG2.090 ± 0.002*2.037 ± 0.160*2.610 ± 0.020*
RLX-MGG3.570 ± 0.27*3.173 ± 0.030*3.870 ± 0.360*

*Significant ( value < 0.05).

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