Table of Contents Author Guidelines Submit a Manuscript
Journal of Pharmaceutics
Volume 2013, Article ID 583536, 13 pages
http://dx.doi.org/10.1155/2013/583536
Research Article

Development of Orodispersible Tablets of Candesartan Cilexetil-β-cyclodextrin Complex

1Department of Pharmaceutics, M.S. Ramaiah College of Pharmacy, Bangalore 54, India
2Department of Pharmacognosy, M.S. Ramaiah College of Pharmacy, Bangalore 54, India

Received 30 January 2013; Revised 24 August 2013; Accepted 24 August 2013

Academic Editor: Giuseppina De Simone

Copyright © 2013 Maddukuri Sravya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study was to investigate the use of inclusion complexation technique employing β-cyclodextrin in improving the dissolution profile of candesartan cilexetil, a BCS class-II drug, and to formulate the inclusion complex into orodispersible tablets. The inclusion complexes were formed by physical mixing, kneading, coevaporation, and lyophilisation methods. Inclusion complexes were characterized by FTIR, DSC, XRD, NMR, and mass spectral studies. Inclusion complexes prepared using kneading, and lyophilisation techniques in the molar ratio 1 : 5 with β-cyclodextrin were used for formulating orodispersible tablets by direct compression with different superdisintegrants like croscarmellose sodium, crospovidone, sodium starch glycolate, and low substituted hydroxypropyl cellulose in varying concentrations. The directly compressible powder was evaluated for precompression parameters, and the prepared orodispersible tablets were evaluated for postcompression parameters. Drug-excipient compatibility studies showed no interaction, and characterization proved the formation of inclusion complex. In vitro disintegration time was found to be within 3 minutes, and all the formulations showed complete drug release of 100% within 20 minutes. The optimized formulation was found to be stable after 6 months and showed no significant change in drug content. This work proved β-cyclodextrins to be effective solubilizing agent in improving the solubility of poorly water soluble drugs.