Seasonal Monitoring of Cardiovascular and Antiulcer Agents’ Concentrations in Stream Waters Encompassing a Capital City
Table 2
Compound-specific LC-MS/MS parameters of the investigated compounds.
Compounds
TS
FragV
MRM1
CE1
MRM2
CE2
MRM ratio
Acebutolol
6.037
2
70
337.1 > 116
25
337.1 > 218
25
16.0
Amlodipine
6.946
2
100
409.1 > 238
10
409.1 > 294.1
10
55.4
Atenolol
1.629
1
130
267.1 > 144.9
25
267.1 > 190
20
45.6
Atenolol-d7
1.612
1
120
274.2 > 145
25
274.2 > 79.1
20
109.3
Atorvastatin
8.082
2
120
559.4 > 440.3
20
559.4 > 466.2
15
14.8
Betaxolol
6.711
2
70
308.1 > 116.1
20
308.1 > 161
20
23.9
Carvedilol
6.880
2
150
407.1 > 224.1
25
407.1 > 283
20
81.8
Cimetidine
1.597
1
90
253.1 > 95
30
253.1 > 159
10
90.7
Cimetidine-d3
1.598
1
70
256.1 > 162.1
10
256.1 > 95.1
25
88.4
Enalapril
6.650
2
140
377.2 > 234.2
15
377.2 > 303.2
15
28.4
Enalapril-d5
6.637
2
120
382.2 > 239.1
15
382.2 > 308.2
15
39.4
Esmolol
6.265
2
100
296.1 > 219
15
296.1 > 254.1
15
26.8
Famotidine
1.551
1
60
338.1 > 189
15
338.1 > 155
30
52.9
Fluvastatin
8.100
2
130
412.2 > 224
30
412.2 > 266.1
15
85.3
Lansoprazole
7.118
2
80
370.1 > 252.1
10
370.1 > 119.1
15
30.0
Lansoprazole-d4
7.107
2
90
374.1 > 252
5
374.1 > 123
20
36.7
Lisinopril
3.051
1
110
406.3 > 84.1
30
406.3 > 246.2
20
24.8
Lovastatin
9.729
2
50
405.3 > 199.1
10
405.3 > 285.1
5
90.7
Metoprolol
6.119
2
140
268.2 > 116.1
15
268.2 > 74.1
20
93.8
Nifedipine
7.712
2
70
347.1 > 315.1
0
347.1 > 254.1
15
56.3
Nimodipine
8.466
2
70
419.2 > 343.1
5
419.2 > 301.1
25
56.6
Nizatidine
1.896
1
100
332.1 > 58.1
30
332.1 > 155
15
40.9
Omeprazole
6.680
2
100
346.1 > 198
10
346.1 > 136.1
30
46.7
Oxprenolol
6.391
2
110
266.1 > 72.2
15
266.1 > 116.2
15
31.5
Pantoprazole
6.899
2
110
384.2 > 200.1
10
384.2 > 138.1
30
91.6
Propanolol
6.588
2
90
260.1 > 116.2
15
260.1 > 183.2
15
71.6
Ramipril
7.139
2
120
417.3 > 234.2
25
417.3 > 130.1
25
22.3
Ranitidine
2.374
1
90
315.2 > 176.1
15
315.2 > 130.1
25
60.9
Simvastatin
9.746
2
80
419.3 > 199.2
5
419.3 > 285.2
5
89.3
Sotalol
1.748
1
100
273.1 > 255
5
273.1 > 133
30
60.8
: retention time (min); TS: time segment; FragV: Fragmentor voltage (V); MRM1: quantifier transition; CE1: collision energy for MRM1 (V); MRM2: qualifier transition; CE2: collision energy for MRM2 (V); MRM ratio: ratio of the two MRMs.