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Journal of Pharmaceutics
Volume 2013, Article ID 906178, 8 pages
Research Article

Development and Evaluation of Dual Cross-Linked Pulsatile Beads for Chronotherapy of Rheumatoid Arthritis

Department of Pharmaceutics, H.R. Patel Institute of Pharmaceutical Education and Research, Dhule, Shirpur 425405, Maharashtra, India

Received 29 September 2012; Revised 19 November 2012; Accepted 24 November 2012

Academic Editor: Nayanabhirama Udupa

Copyright © 2013 Abanesh kumar Bansal and Vishal Pande. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In the present investigation, pulsatile release beads were prepared by ionic gelation technique. Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion phase of different concentrations of calcium chloride solution followed by aluminium chloride solution. The formulated beads were further coated by Eudragit L & S 100 in the ratio 1 : 2 w/w in order to achieve desired lag time. In vitro release study showed lag time of 5–8 h before release of lornoxicam from the formulated beads. Thus, formulated dual cross-linked beads when administered at bed time may release lornoxicam when needed most for chronotherapeutics of early morning rheumatoid arthritis attacks in chronic patients.