Development and Evaluation of Dual Cross-Linked Pulsatile Beads for Chronotherapy of Rheumatoid Arthritis

Table 1

Composition of single and dual cross-linked beads formulation.

Batch code	Dispersion phase				Dispersion medium
	Lornoxicam (mg)	Sodium alginate (mg)	Pectin (mg)	Distilled water (mL)	CaCl2 (% w/v)	AlCl3 (% w/v)	Cross linking time (min.)
P1	50	400	100	10	5	—	10
P2	50	350	150	10	5	—	10
P3	50	300	200	10	5	—	10
P4	50	450	50	10	5	—	10
P5	50	250	250	10	5	—	10
P6	50	400	100	10	5	5	10
P7	50	450	50	10	5	5	10
P8	50	400	100	10	5	—	15
P9	50	400	100	10	5	—	20