Dissolution Rate Enhancement, Design and Development of Buccal Drug Delivery of Darifenacin Hydroxypropyl <i>β</i>-Cyclodextrin Inclusion Complexes

<table class="table-group" id="tab8"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td align="left">Formulation code</td><td align="center">Bioadhesive strength (g)</td><td align="center">Force of adhesion (N)</td><td align="center">Bond strength (N m<sup>−2</sup>)</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td align="left">Pb1</td><td align="center"><span style="width: 74.362503px;"><svg height="11.4" id="M119" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 74.362503 11.4" width="74.362503" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg></span></td><td align="center">0.0945</td><td align="center">9457.13</td></tr><tr><td align="left">Pb2</td><td align="center"><span style="width: 82.525002px;"><svg height="11.4" id="M120" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 82.525002 11.4" width="82.525002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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t98.5 -62.5q61 48 61 124q0 59 -29.5 90t-69.5 31zM248 20q46 0 76.5 33.5t30.5 89.5q0 50 -39 85.5t-110 71.5q-81 -54 -81 -137q0 -67 35.5 -105t87.5 -38z" id="x38"></path></g><g transform="matrix(.017,-0,0,-.017,40.35,10.963)"><path d="M535 290h-212v-206h-58v206h-213v50h213v193h58v-193h212v-50zM535 -22h-483v50h483v-50z" id="xB1"></path></g><g transform="matrix(.017,-0,0,-.017,54.102,10.963)"><path d="M241 635q53 0 94 -28.5t63.5 -76t33.5 -102.5t11 -116q0 -58 -11 -112.5t-34 -103.5t-63.5 -78.5t-94.5 -29.5t-95 28t-64.5 75t-34.5 102.5t-11 118.5q0 58 11.5 112.5t34.5 103t64.5 78t95.5 29.5zM238 602q-32 0 -55.5 -25t-35.5 -68t-17.5 -91t-5.5 -105
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</svg></span></td><td align="center">0.101</td><td align="center">1017.24</td></tr><tr><td align="left">Pb3</td><td align="center"><span style="width: 82.525002px;"><svg height="11.4" id="M121" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 82.525002 11.4" width="82.525002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg></span></td><td align="center">0.106</td><td align="center">1064.28</td></tr><tr><td align="left">Pb4</td><td align="center"><span style="width: 82.525002px;"><svg height="11.2875" id="M122" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 82.525002 11.2875" width="82.525002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg></span></td><td align="center">0.114</td><td align="center">1149.54</td></tr><tr><td align="left">Pb5</td><td align="center"><span style="width: 82.525002px;"><svg height="11.2875" id="M123" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 82.525002 11.2875" width="82.525002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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q0 45 -26.5 69.5t-68.5 24.5q-67 0 -120 -79l-20 20l43 63q51 56 127 56h1q66 0 107 -37t41 -95q0 -42 -31 -71q-22 -23 -68 -54z" id="x33"></path></g>
</svg></span></td><td align="center">0.122</td><td align="center">1228.92</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Bioadhesive parameters of HPMC K15 patches.

Journal of Pharmaceutics

tab8

Table 8

Table 8: Dissolution Rate Enhancement, Design and Development of Buccal Drug Delivery of Darifenacin Hydroxypropyl <i>β</i>-Cyclodextrin Inclusion Complexes 

Table 8 | Dissolution Rate Enhancement, Design and Development of Buccal Drug Delivery of Darifenacin Hydroxypropyl β-Cyclodextrin Inclusion Complexes 