Formulation and Characterization of Solid Dispersion Prepared by Hot Melt Mixing: A Fast Screening Approach for Polymer Selection

Figure 1

Images of films obtained after evaporation of solvent after 24 hours. All the images on the Left are taken by a high resolution digital camera and the images on the right are taken with an optical microscope using a crosspolarized light at 90°. Film of glyceryl monostearate with 20% w/w TEC as observed by visual (a1) and optical microscopy (a2), film of hydroxypropyl methyl cellulose with 20% w/w TEC as observed by visual (b1) and optical microscopy (b2), film of hydroxyl propyl cellulose with 20% w/w PEG1000 and 20% w/w sulindac as observed by visual (c1) and optical microscopy (c2), film of chitosan with 20% w/w glycerol polyethylene glycol oxystearate and 50% w/w sulindac as observed by visual (d1) and optical microscopy (d2), film of povidone with 20% w/w C 40 as observed by visual (e1) and optical microscopy (e2), crystals of sulindac as observed under bight field (f1) and polarized light at 90° (f2) by optical microscope.