Formulation and Characterization of Solid Dispersion Prepared by Hot Melt Mixing: A Fast Screening Approach for Polymer Selection

Table 1

Different polymers and plasticizers along with drug tested by film technique.

Polymer^a	Plasticizer^b	Solvent used^c
GB, LM, SM, PPP, CO, PO, P407, GM, TPGS, HPC	—	Chloroform (25–50 mg/mL)
HPMC	—	Methanol : dichloromethane (2 : 1, 25 mg/mL)
Chitosan	—	Water : glacial acetic acid (2 : 1, 20 mg/mL)
—	PEG1000, PEG1000, TEC, C 40	Soluble/miscible with ethanol and chloroform

aGB (glyceryl behenate), LM (lauroyl macrogolglycerides), SM (stearoyl macrogolglycerides), PPP (polyvinyl pyrrolidone-polyvinyl chloride-polyvinyl acetate copolymer), CO (copovidone), PO (povidone), P407 (poloxamer 407), GM (glyceryl monostearate), TPGS (D-alpha-tocopherol polyethylene glycol 1000 succinate), HPC (hydroxypropyl cellulose), HPMC (hydroxypropyl methyl cellulose), TEC (triethyl citrate), and C40 (glycerol polyethylene glycol oxystearate).
^bPlasticizers are used in the study at two levels of 10% w/w and 20% w/w of polymer.
^cValues in the parenthesis are the solubility of the polymer in the given solvent.