A Critical Appraisal of Solubility Enhancement Techniques of Polyphenols

Table 3

Different methods for solid dispersions of ellagic acid [37].

Method	Composition	Procedure
Spray-dried solid dispersion	Acetone : ethanol (1 : 4 v/v) solution, ellagic acid, polyvinylpyrrolidone (PVP), carboxymethyl cellulose acetate butyrate (CMCAB), hydroxypropyl methyl cellulose acetate succinate (HPMCAS)	Acetone : ethanol solution was used to dissolve mixtures of EA/polymer followed by spray drying of the resultant dispersion under operating conditions of 90°C inlet temperature, 57–60°C outlet temperature, 9 mL/min feed rate, and 350 L/h nitrogen flow.
Coprecipitated solid dispersion	Ellagic acid, tetrahydrofuran (THF), cellulose acetate adipate propionate (CAAdP)	A mixture of EA/CAAdP was dissolved in THF followed by dropwise addition of the solution in deionized water with stirring.
Solid dispersion by rotary evaporation	Ellagic acid (20 mg), PVP (90 mg), CAAdP (90 mg), acetonitrile : ethanol (1 : 1 v/v) solution (40 mL)	EA, PVP, and CAAdP were dissolved in acetonitrile : ethanol solution followed by concentrating the solution with rotary evaporation