Combinative Particle Size Reduction Technologies for the Production of Drug Nanocrystals

Figure 2

Particle size reduction performance of standard and combinative technologies. Six levels: premilling (1), 1 HPH cycle at 1500 bar/1 hour of WBM (2), 5 cycles/2 hours (3), 10 cycles/4 hours (4), 15 cycles/8 hours (5), and 20 cycles/24 hours (6).