Development and Evaluation of Novel Self-Nanoemulsifying Drug Delivery Systems Based on a Homolipid from Capra hircus and Its Admixtures with Melon Oil for the Delivery of Indomethacin
Table 2
Composition of indomethacin-loaded SNEDDS based on a blend of goat fat and melon oil.
Batch
Ratio* O : S : CS
Goat fat (g)
Melon oil (g)
Tween 65 (g)
Tween 80 (g)
Span 85 (g)
Carbosil (mg)
Indomethacin (mg)
1C
20 : 60 : 20
0.4
0.4
1.2
1.2
0.8
—
400
1D
20 : 60 : 20
0.4
0.4
1.2
1.2
0.8
300
400
2C
35 : 45 : 20
0.7
0.7
0.9
0.9
0.8
—
400
2D
35 : 45 : 20
0.7
0.7
0.9
0.9
0.8
300
400
3C
25 : 55 : 20
0.5
0.5
1.1
1.1
0.8
—
400
3D
25 : 55 : 20
0.5
0.5
1.1
1.1
0.8
300
400
4C
25 : 60 : 15
0.5
0.5
1.2
1.2
0.8
—
400
4D
25 : 60 : 15
0.5
0.5
1.2
1.2
0.8
300
400
Ratio of oil blend (goat fat and melon oil) : surfactant blend (Tween 65 and Tween 80) : cosurfactant (Span 85).
