New preclinical microbicide candidates with their mechanism of action.
|Mechanism of action||Candidates|
|Vaginal defense enhancer||Genetically engineered probiotics, mucocept HIV, RANTES peptides, and Lactobacillus delivered cyanovirin-N|
|Entry/fussion inhibitors ||Aptamers, betacyclodextrin, flavinoids, porphyrins, siRNA, silver nanoparticles, ISIS 5060, reterocyclines, and TatCD|
|Combination approaches||Buffer gel with dendrimers, M167, BMS, and other ARV|
|Microbicide combined with devices||Duet cervical barrier and condoms with alkyl sulfate coating|
|Uncharacterized mechanism||CO (ciclo piroxolamine)|
|Surfactants||Alkyl sulfates (surfactants and chaotropic agents)|