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Journal of Pharmaceutics
Volume 2014 (2014), Article ID 378048, 9 pages
http://dx.doi.org/10.1155/2014/378048
Review Article

Emerging Trends in Noninvasive Insulin Delivery

Department of Pharmacy, School of Medical & Allied Sciences, Galgotias University, Yamuna Expressway, Greater Noida, Uttar Pradesh, India

Received 2 January 2014; Revised 26 March 2014; Accepted 16 April 2014; Published 14 May 2014

Academic Editor: Praneet Opanasopit

Copyright © 2014 Arun Verma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This paper deals with various aspects of oral insulin delivery system. Insulin is used for the treatment of diabetes mellitus, which is characterized by the elevated glucose level (above the normal range) in the blood stream, that is, hyperglycemia. Oral route of administration of any drug is the most convenient route. Development of oral insulin is still under research. Oral insulin will cause the avoidance of pain during the injection (in subcutaneous administration), anxiety due to needle, and infections which can be developed. Different types of enzyme inhibitors, like sodium cholate, camostat, mesilate, bacitracin, leupeptin, and so forth, have been used to prevent insulin from enzymatic degradation. Subcutaneous route has been used for administration of insulin, but pain and itching at the site of administration can occur. That is why various alternative routes of insulin administration like oral route are under investigation. In this paper authors summarized advancement in insulin delivery with their formulation aspects.