Design and Evaluation of Voriconazole Eye Drops for the Treatment of Fungal Keratitis

Table 1

Effect of the addition of different polymers to voriconazole ophthalmic solutions at different concentrations on viscosity of solutions, bioadhesion component, and force of bioadhesion.

Voriconazole ophthalmic solutions; (1.5% w/v, pH 7.0)	Viscosity of solutions; at 100 rpm (cP)	Viscosity of bioadhesive component; at 100 rpm (cP)	Force of bioadhesion; (dyne/cm^2)
Control	3.01±0.02	165.20±0.200	19.81±0.333
PVA 1.4%	13.10±0.100^††	166.63±0.378^††	47.88±0.254^†††
CS 0.20%	15.23±0.246^††	192.33±0.152^††	52.61±0.631^†††
GG 1.5%	62.66±0.321^††	247.70±0.264^††	57.90±0.441^†††
SA 2.00%	132.50±0.500^††	321.43±0.152^††	64.38±0.254^†††
Gelrite 0.5%	147.10±0.100^††	340.70±0.200^††	72.16±0.333^†††
SCMC 2.5%	167.80±0.100^††	365.13±0.152^††	78.33±0.254^†††
XG 1.5%	180.20±0.264^††	381.10±0.100^††	84.33±0.166^†††

∗PVA refers to polyvinyl alcohol, CS refers to chitosan, GG refers to guar gum, SA refers to sodium alginate, SCMC refers to sodium carboxymethyl cellulose, and XG refers to xanthan gum.
Values are mean ± SE of 3 solutions viscosity in each group.
^†Statistically significant difference at 𝑃<0.05; ^††statistically significant difference at 𝑃<0.01; ^†††statistically significant difference at 𝑃<0.001 from control (voriconazole-HP-β-CD based solutions 1.5%, pH 7.0) as determined by one-way ANOVA followed by Dunnett’s test.