Development and Evaluation of Mouth Dissolving Films of Amlodipine Besylate for Enhanced Therapeutic Efficacy

Table 2

Physicomechanical properties of different AMLO MDFs*.

Formulations	Drug content (mg/cm^2) (𝑛=3)	Mass variation; (mg)	Thickness (μm) (𝑛=6)	Disintegration time (sec)
				Drop method (𝑛=3)	Petri dish method (𝑛=3)
F1	0.911±0.0046	3.40±0.20	56.67±5.47	19.67±1.53	36.33±1.15
F2	1.244±0.0085	3.60±0.17	68.33±4.08	14.67±0.58	31.33±1.53
F3	1.241±0.0095	3.57±0.15	68.33±4.08	10.33±0.58	20.67±0.58
F4	0.904±0.0055	3.47±0.21	56.67±5.16	23.67±0.58	45.33±2.52
F5	1.240±0.0134	3.77±0.15	68.33±0.00	21.33±0.58	36.67±1.53
F6	1.233±0.0232	3.73±0.16	68.33±0.00	12.33±1.15	23.33±0.58
F7	0.958±0.0105	3.67±0.21	58.33±4.08	26.33±0.58	55.33±0.58
F8	1.208±0.0133	3.93±0.06	70.00±0.00	21.67±0.58	49.33±0.58
F9	1.095±0.0391	3.97±0.12	70.00±0.00	17.67±0.58	30.67±2.08
F10	0.964±0.008	3.77±0.12	60.00±0.00	141.67±2.89	723.33±5.77
F11	1.247±0.049	4.10±0.10	70.00±0.00	62.67±2.31	656.67±5.77
F12	1.216±0.013	4.05±0.10	70.00±0.00	55.00±1.73	568.33±2.89

∗No change in the values after a 6-month period was observed.