Development and Evaluation of Mouth Dissolving Films of Amlodipine Besylate for Enhanced Therapeutic Efficacy

Table 4

Drug release kinectics data.

Formulations	DP10 (mean ± SD)	𝑅^2 (first order plot)	Mean “𝑘” (sec^−1) (0–50 sec)	Higuchi constant 𝐾𝐻 (sec^−1/2)	𝑅^2 (Higuchi plot)
F1	18.36±0.23	0.977	0.0345	10.30	0.956
F2	26.44±0.94	0.981	0.0391	12.16	0.977
F3	28.89±1.38	0.973	0.0529	14.13	0.964
F4	12.52±1.47	0.997	0.0161	8.45	0.979
F5	22.85±0.93	0.961	0.0345	10.30	0.956
F6	24.74±1.42	0.959	0.0437	13.72	0.950
F7	9.52±1.32	0.976	0.0138	7.52	0.967
F8	13.00±1.94	0.983	0.0299	10.30	0.956
F9	19.18±1.15	0.971	0.0345	12.58	0.936
F10	6.96±0.40	0.975	0.00691	4.90	0.961
F11	11.38±2.25	0.985	0.00921	5.89	0.952
F12	14.92±0.67	0.934	0.01382	5.23	0.938

DP₁₀: drug percent released at 10 sec.