The Population Pharmacokinetic Models of Tacrolimus in Chinese Adult Liver Transplantation Patients

Table 4

Parameter estimates of final model and bootstrap validation.

Parameter typical	Parameter estimate	SE%	Bootstrap
			Median	2.5th, 97.5th percentiles
CL/𝐹 (L/h)	11.2	0.28	11.7	7.59, 18.4
𝑉2 (L)	406	30	375	262, 570
𝑄 (L/h)	57.3	4.86	66.3	48.5, 113
𝑉3 (L)	503	18.5	526	363, 853
𝑘𝑎 (h^−1)	0.723	72.4	0.764	0.545, 1.43
θDOSE	0.371	11.1	0.337	0.14, 0.511
θPOD	0.127	3.8	0.127	0.0906, 0.183
ωCL/𝐹 (%)	16.2	4.67	23.98	10.82, 40.2
ω 𝑉2/𝐹 (%)	163	164	120	67.2, 170
ω 𝑄/𝐹 (%)	19.7	21.4	26.5	8.9, 47.8
ω 𝑉3/𝐹 (%)	199	231	127	79.7, 237
ω 𝑘𝑎 (%)	74.3	57.5	81.91	40.2, 110
σ (%)	26.54	0.868	25.1	22.1, 28.2