Development of Budesonide Loaded Biopolymer Based Dry Powder Inhaler: Optimization, In Vitro Deposition, and Cytotoxicity Study

Table 4

Characterization of in vitro deposition of final formulated and commercial DPI by ACI.

Formulation	Particle size of dry powder [0.9]^a	Angle of repose [𝜃]	Bulk density^a [g/cm^3]	Tapped density [g/cm^3]	Carr’s index^a	Hausner ratio^a	MMAD^a [μm]	GSD^a [μm]	FPF^a [%]
Optimized DPI (F7)	3.059 ± 0.03	25 ± 0.01	0.076 ± 0.01	0.095 ± 0.02	20.00 ± 0.01	0.80 ± 0.10	1.16 ± 0.01	3.78 ± 0.07	56.18 ± 0.05
Commercial DPI	1.521 ± 0.04	24 ± 0.01	0.124 ± 0.01	0.154 ± 0.01	19.48 ± 0.03	0.80 ± 0.01	5.04 ± 0.03	1.44 ± 0.02	22.83 ± 0.06

aAll the determinations performed in triplicate and values are expressed as mean (values = average ± SD).