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Journal of Pharmaceutics
Volume 2014, Article ID 808167, 8 pages
http://dx.doi.org/10.1155/2014/808167
Research Article

Formulation Development and Evaluation of Fast Disintegrating Tablet of Cetirizine Hydrochloride: A Novel Drug Delivery for Pediatrics and Geriatrics

1Department of Pharmaceutics, Rayat Bahra Institute of Pharmacy, Hoshiarpur-146001, Punjab, India
2Quantum Solutions, Chandigarh, Punjab, India
3CSIR Institute of Microbial Technology, Chandigarh, Punjab, India
4CT Institute of Pharmaceutical Sciences, Jalandhar-144020, Punjab, India

Received 16 November 2013; Revised 4 January 2014; Accepted 6 January 2014; Published 18 February 2014

Academic Editor: Jae Hyung Park

Copyright © 2014 Deepak Sharma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Recent developments in fast disintegrating tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets. The objective of the present study was to prepare the fast disintegrating tablet of Cetirizine Hydrochloride for allergic and respiratory disorders. As precision of dosing and patient's compliance become important prerequisite for a long-term treatment, there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling, and patient’s acceptability. Hence, the present investigation was undertaken with a view to develop a fast disintegrating tablet of Cetirizine Hydrochloride which offers a new range of products having desired characteristics and intended benefits. Superdisintegrants such as Sodium Starch Glycolate were optimized. Different binders were optimized along with optimized superdisintegrant concentration. The tablets were prepared by direct compression technique. The tablets were evaluated for hardness, friability, weight variation, wetting time, disintegration time and uniformity of content. Optimized formulation was evaluated by in vitro dissolution test, drug excipient compatibility and accelerated stability study. It was concluded that fast disintegrating tablets of Cetirizine Hydrochloride were formulated successfully with desired characteristics which disintegrated rapidly, provide rapid onset of action, and enhance the patient convenience and compliance.