Formulation Development and Evaluation of Fast Disintegrating Tablet of Cetirizine Hydrochloride: A Novel Drug Delivery for Pediatrics and Geriatrics

Table 6

Evaluation parameters for the optimization of Polyvinylpyrrolidone (PVP K-30) or Microcrystalline Cellulose as binder with optimized concentration of Sodium Starch Glycolate.

Formula number	Evaluation parameters
	Weight variation (IP)	Friability (%)	*Hardness (Kg/cm^2) ± SD	**Disintegration time (Sec) ± SD
F1	Passed	0.1	2.2±0.28	60±1.78
F2	Passed	0.2	1.8±0.28	𝟒𝟗±𝟏.𝟔𝟕
F3	Passed	0.5	2.0±0.00	69±2.89
F4	Passed	0.3	3.2±0.76	83±2.40
F5	Passed	0.3	1.6±0.50	90±5.16
F6	Passed	0.8	2.5±0.50	120±5.77
F7	Passed	0.8	2.0±0.00	145±5.43
F8	Passed	0.1	1.5±0.50	𝟑𝟕±𝟑.𝟏𝟑
F9	Passed	0.1	1.5±0.28	47±1.34
F10	Passed	0.2	1.5±0.28	62±1.10
F11	Passed	0.1	1.8±0.28	75±1.32
F12	Passed	0.1	1.5±0.28	82±2.08
F13	Passed	0.1	1.8±0.28	96±1.84
F14	Passed	0.1	1.8±0.28	105±2.73

∗Average of three determinations, ∗∗average of six determinations.
Bold font refers to disintegration time of 2% PVP K-30 and disintegration time of 1% MCC.