Formulation and Evaluation of Multilayered Tablets of Pioglitazone Hydrochloride and Metformin Hydrochloride

Table 1

Composition of immediate release layer formulations of pioglitazone HCl.

Formulation code	F1	F2	F3	F4
Pioglitazone HCl (mg)	15	15	15	15
Crospovidone (mg)	1.5	2.25	3	3.75
Avicel PH 102 (mg)	2.25	2.25	2.25	2.25
Lactose (mg)	59.25	58.5	57.75	57
Magnesium stearate (mg)	1	1	1	1
Talc (mg)	1	1	1	1
Total weight (mg)	80	80	80	80