Formulation and Evaluation of Multilayered Tablets of Pioglitazone Hydrochloride and Metformin Hydrochloride

Table 4

Flow properties of granules prepared by direct compression method.

Batch number	Angle of repose	Bulk density (g/mL)	Tapped density (g/mL)	Compressibility index (%)	Hausner’s ratio	Content uniformity (%)
F1	31.9±0.03	0.63±0.01	0.74±0.04	11.9±0.02	1.17±0.05	98.8±0.06
F2	34.5±0.06	0.75±0.08	0.89±0.02	12.6±0.04	1.18±0.04	100.7±0.02
F3	33.8±0.08	0.65±0.03	0.76±0.07	14.4±0.05	1.16±0.06	98.5±0.07
F4	32.6±0.02	0.72±0.01	0.81±0.06	12.4±0.06	1.12±0.03	97.8±0.04
F5	32.6±0.05	0.43±0.08	0.51±0.02	14.8±0.06	1.18±0.06	94.8±0.04
F6	33.8±0.04	0.51±0.04	0.59±0.05	13.9±0.03	1.15±0.04	99.6±0.03
F7	30.5±0.06	0.46±0.05	0.55±0.08	11.4±0.07	1.19±0.01	97.9±0.06
F8	34.7±0.08	0.39±0.01	0.46±0.01	12.7±0.04	1.17±0.09	98.6±0.01