Formulation and Evaluation of Multilayered Tablets of Pioglitazone Hydrochloride and Metformin Hydrochloride

Table 8

Release kinetics of metformin HCl controlled release layer (F5–F13).

Batch number	Zero order		Higuchi		Korsmeyer-Peppas model			First order
	𝑟^2	𝑘	𝑟^2	𝑘	𝑟^2	𝑘-𝑎	𝑛	𝑟^2	𝑘
F5	0.9018	17.42	0.9924	42.15	0.3179	1.995	0.300	0.0098	0.0806
F6	0.9075	14.56	0.9966	39.21	0.1962	1.5995	0.204	0.0362	0.1105
F7	0.9533	10.28	0.9681	31.57	0.4287	1.8407	0.265	0.4647	0.2118
F8	0.9594	9.99	0.9749	30.69	0.4556	1.8155	0.259	0.4866	0.1865
F9	0.9511	18.14	0.9851	42.59	0.2937	1.9319	0.286	0.0138	0.1381
F10	0.8524	11.80	0.9856	35.75	0.0456	1.2217	0.087	0.0698	0.1450
F11	0.9062	10.30	0.9960	32.93	0.1318	1.1825	0.120	0.3679	0.2533
F12	0.9044	9.44	0.9878	30.09	0.2408	1.4256	0.154	0.4158	0.1888
F13	0.9932	9.66	0.9525	31.25	0.1307	1.6749	0.224	0.3698	0.2809