Research Article
Enhancement of Solubility of Lamotrigine by Solid Dispersion and Development of Orally Disintegrating Tablets Using 32 Full Factorial Design
Table 3
Composition of drug, polymers, and different excipients.
| | Ingredients | ODT1 | ODT2 | ODT3 | ODT4 | ODT5 | ODT6 | ODT7 | ODT8 | ODT9 |
| | LB1 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | | SSG | 1.5 | 3 | 4.5 | 1.5 | 3 | 4.5 | 1.5 | 3 | 4.5 | | Crospovidone | 1.5 | 1.5 | 1.5 | 3 | 3 | 3 | 4.5 | 4.5 | 4.5 | | Mannitol | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | | Avicel pH 102 | 71.5 | 70 | 68.5 | 70 | 68.5 | 67 | 68.5 | 67 | 65.5 | | Sodium saccharin | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | | Mg stearate | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
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