Enhancement of Solubility of Lamotrigine by Solid Dispersion and Development of Orally Disintegrating Tablets Using 3² Full Factorial Design

Table 4

Precompression parameters of blends SD ± ().

Parameters; formulation	Bulk density; (g/cc)	Tapped density; (g/cc)	Hausner’s Ratio	Compressibility; index (%)	Angle of repose; (°)
ODT1	0.598 ± 0.007	0.782 ± 0.006	1.149 ± 0.014	12.995 ± 1.105	22 ± 3.023
ODT2	0.590 ± 0.010	0.672 ± 0.006	1.138 ± 0.027	12.107 ± 2.119	24 ± 1.564
ODT3	0.609 ± 0.016	0.702 ± 0.011	1.146 ± 0.025	12.738 ± 1.958	23 ± 2.654
ODT4	0.669 ± 0.024	0.757 ± 0.025	1.131 ± 0.015	11.599 ± 1.213	25 ± 1.589
ODT5	0.598 ± 0.014	0.680 ± 0.018	1.137 ± 0.024	12.078 ± 1.916	28 ± 1.852
ODT6	0.668 ± 0.031	0.754 ± 0.010	1.129 ± 0.038	11.362 ± 2.985	26 ± 1.324
ODT7	0.621 ± 0.015	0.734 ± 0.025	1.165 ± 0.034	11.654 ± 2.364	29 ± 1.265
ODT8	0.581 ± 0.013	0.639 ± 0.016	1.148 ± 0.027	12.185 ± 2.139	24 ± 2.654
ODT9	0.565 ± 0.015	0.695 ± 0.011	1.139 ± 0.023	12.952 ± 1.912	29 ± 1.632