Research Article
Enhancement of Solubility of Lamotrigine by Solid Dispersion and Development of Orally Disintegrating Tablets Using 32 Full Factorial Design
Table 4
Precompression parameters of blends SD ± (
).
| Parameters formulation | Bulk density (g/cc) | Tapped density (g/cc) | Hausner’s Ratio | Compressibility index (%) | Angle of repose (°) |
| ODT1 | 0.598 ± 0.007 | 0.782 ± 0.006 | 1.149 ± 0.014 | 12.995 ± 1.105 | 22 ± 3.023 | ODT2 | 0.590 ± 0.010 | 0.672 ± 0.006 | 1.138 ± 0.027 | 12.107 ± 2.119 | 24 ± 1.564 | ODT3 | 0.609 ± 0.016 | 0.702 ± 0.011 | 1.146 ± 0.025 | 12.738 ± 1.958 | 23 ± 2.654 | ODT4 | 0.669 ± 0.024 | 0.757 ± 0.025 | 1.131 ± 0.015 | 11.599 ± 1.213 | 25 ± 1.589 | ODT5 | 0.598 ± 0.014 | 0.680 ± 0.018 | 1.137 ± 0.024 | 12.078 ± 1.916 | 28 ± 1.852 | ODT6 | 0.668 ± 0.031 | 0.754 ± 0.010 | 1.129 ± 0.038 | 11.362 ± 2.985 | 26 ± 1.324 | ODT7 | 0.621 ± 0.015 | 0.734 ± 0.025 | 1.165 ± 0.034 | 11.654 ± 2.364 | 29 ± 1.265 | ODT8 | 0.581 ± 0.013 | 0.639 ± 0.016 | 1.148 ± 0.027 | 12.185 ± 2.139 | 24 ± 2.654 | ODT9 | 0.565 ± 0.015 | 0.695 ± 0.011 | 1.139 ± 0.023 | 12.952 ± 1.912 | 29 ± 1.632 |
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