Freeze Dried Quetiapine-Nicotinamide Binary Solid Dispersions: A New Strategy for Improving Physicochemical Properties and Ex Vivo Diffusion

Table 4

Results of in vitro gut permeation of QF through duodenum and jejunum compared to the coamorphous dispersion F6.

Formula	Duodenum			Jejunum
	Flux rate; (mg/cm^2/h)	Lag time; (min)	Regression; R^2	Flux rate; (mg/cm^2/h)	Lag time; (min)	Regression; R^2
Pure QF	0.027	38.22	0.97	0.028	32.51	0.98
QF-NIC (F6)	0.041	12.15	0.99	0.036	17.72	0.99