Journal of Pharmaceutics / 2016 / Article / Tab 4

Research Article

Freeze Dried Quetiapine-Nicotinamide Binary Solid Dispersions: A New Strategy for Improving Physicochemical Properties and Ex Vivo Diffusion

Table 4

Results of in vitro gut permeation of QF through duodenum and jejunum compared to the coamorphous dispersion F6.

Formula Duodenum Jejunum
Flux rate
(mg/cm2/h)
Lag time
(min)
Regression
R2
Flux rate
(mg/cm2/h)
Lag time
(min)
Regression
R2

Pure QF0.02738.220.970.02832.510.98
QF-NIC (F6)0.04112.150.990.03617.720.99

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