Research Article
Formulation and Evaluation of Antibacterial Creams and Gels Containing Metal Ions for Topical Application
Table 1
Composition of the topical cream formulations.
| | | Amount of each ingredient (%); formulations are coded from 1 to 20 | | Ingredients | C1 | C2 | C3 | C4 | C5 | C6 | C7 | C8 | C9 | C10 | C11 | C12 | C13 | C14 | C15 | C16 | C17 | C18 | C19 | C20 |
| | Copper sulfate | 3 | | Zinc sulfate | 3 | | Corn oil | 4 | 4 | 4 | 4 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | | MCT | 4 | 4 | 4 | 4 | — | 3 | 3 | 3 | 5 | 5 | 4 | 4 | — | — | — | 6 | — | 4 | 4 | 4 | | Sweet Almond oil | 4 | 4 | 4 | 4 | 5 | 4 | 4 | 5 | — | — | — | — | 10 | 10 | 6 | — | 5 | 4 | 4 | 4 | | Coconut oil | — | — | — | — | — | — | — | — | 5 | 5 | 4 | 4 | — | — | — | 4 | 5 | 4 | 4 | 4 | | Cocoa butter | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 3 | — | — | — | | Soy bean oil | — | — | — | — | 5 | 6 | 6 | 6 | 5 | 5 | 4 | 4 | — | — | 6 | 4 | 4 | — | — | — | | PEG-16 Macadamia | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 4 | — | — | — | — | | PEG-10 Sunflower | — | — | — | — | — | — | — | — | — | — | — | — | 2 | 2 | — | — | — | — | — | — | | Tefose HC | 4 | 5 | 6 | 6 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | | Prolipid 141 | 5 | 6 | 5 | 7 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | | PEG-8 Beeswax | 7 | 8 | 6 | 6 | — | — | — | — | — | 4 | 6 | 7 | — | — | — | — | — | 7 | 6 | 7 | | Cithrol GMS 40 | 5 | 6 | 6 | 6 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 3 | | Span 80 | — | — | — | — | — | — | — | — | — | — | — | — | 1.05 | 2.25 | 1.57 | 1.42 | 1.77 | — | — | — | | Tween 60 | — | — | — | — | — | — | — | — | — | — | — | — | 0.95 | 2.75 | 2.43 | 2.58 | 2.23 | — | — | — | | Stearyl Alcohol | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 4 | 5 | — | 5 | 2 | | Stearic acid | — | — | — | — | 3 | 2 | 3 | 4 | 4 | 4 | 4 | 5 | 2 | 2 | 5 | — | — | 4 | — | — | | Cetyl alcohol | — | — | — | — | 5 | 4 | 5 | 7 | 6 | 6 | 6 | 7 | 2 | 4 | 5 | 3 | 5 | 6 | 6 | 6 | | Arlacel 165 | — | — | — | — | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | — | — | — | — | — | 5 | 5 | 5 | | Urea | — | — | — | — | 3 | — | — | — | — | — | — | — | 4 | 4 | 3 | 3 | — | — | — | — | | 2% HPMC gel | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 5 | — | — | | Xanthan gum | — | — | — | — | — | 0.5 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 | — | — | 0.5 | 0.5 | — | — | — | — | | Carrageenan | 0.35 | 0.35 | 0.35 | 0.35 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | | Glycerin | 5 | | Citric acid | 1 | | BHT | 0.05 | | DI water | qs ad to 100 |
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MCT: medium chain triglycerides; HPMC: hypromellose; BHT: butylated hydroxytoluene.
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