Research Article
Cellulose Acetate 398-10 Asymmetric Membrane Capsules for Osmotically Regulated Delivery of Acyclovir
Table 1
Actual and coded values of independent variables used for fabrication of AMCs of acyclovir in 23 full factorial design.
| | Formulation code | Cellulose acetate
398-10 (% w/v)
(A) | Glycerol (% v/v)
(B) | Sodium lauryl sulphate (mg)
(C) | Dependent variable |
| | F1 | 10 (−1) | 10 (−1) | 215 (−1) |
% (Y1) | | F2 | 15 (+1) | 10 (−1) | 215 (−1) | | F3 | 10 (−1) | 18 (+1) | 215 (−1) | | F4 | 15 (+1) | 18 (+1) | 215 (−1) | | F5 | 10 (−1) | 10 (−1) | 290 (+1) | | F6 | 15 (+1) | 10 (−1) | 290 (+1) | | F7 | 10 (−1) | 18 (+1) | 290 (+1) | | F8 | 15 (+1) | 18 (+1) | 290 (+1) | | F9 | 12 | (14) | (250) |
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Extra design checkpoint; cumulative drug release.
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