Evaluation of the Disintegrant Properties of Native Starches of Five New Cassava Varieties in Paracetamol Tablet Formulations
Table 3
Tensile strength (), crushing strength (), friability (), disintegration time (), and DER [(/)/DT] and DERc ratios for paracetamol tablets containing different concentrations of the cassava starch disintegrants.
Type of cassava starch
Starch concentration (% w/w)
(N/cm2)
(N)
(%)
(min)
DER
V10
5.0
75.8
63.2
0.74
12.58
6.79
0.45
7.5
74.6
55.7
0.90
13.10
4.72
0.35
10.0
82.6
66.0
ND
3.20
—
—
V20
5.0
91.2
77.4
0.88
14.00
6.28
0.42
7.5
112.4
97.4
0.46
12.00
17.64
1.32
10.0
67.7
50.7
0.43
5.00
23.58
2.49
V30
5.0
96.4
74.3
0.92
14.10
5.73
0.38
7.5
78.0
65.8
0.89
13.06
5.66
0.42
10.0
73.1
61.3
0.71
9.10
9.49
1.00
V40
5.0
87.2
76.1
0.28
13.40
20.28
1.35
7.5
94.7
94.3
0.71
10.00
13.28
0.99
10.0
69.8
55.7
0.27
4.45
46.36
4.90
V50
5.0
117.6
98.4
0.29
14.30
23.73
1.58
7.5
84.4
69.7
0.91
11.36
6.74
0.50
10.0
82.6
62.8
0.43
7.55
19.34
2.04
5.0
126.0
96.1
0.45
14.20
15.04
—
7.5
102.5
79.0
0.45
13.15
13.35
—
10.0
87.7
64.0
0.59
11.46
9.46
—
(a) ND: not determined due to the break-up of the tablets; (b) is maize starch BP, the reference disintegrant used.
