Formulation and Evaluation of New Glimepiride Sublingual Tablets

Table 1

The table illustrates the materials and their quantities which used to formulate new glymipride subligual tablet formulations (F1, F2, F3, F4, and F5).

Number	Material	Formula code
		F1		F2		F3		F4		F5
		Amount/unit	Actual amount	Amount/unit	Actual amount	Amount/unit	Actual amount	Amount/unit	Actual amount	Amount/unit	Actual amount
1	Glimepiride	0.003 g	0.9 g	0.003 g	0.9 g	0.002 g	0.6 g	0.003 g	0.9 g	3 mg	0.9 g
2	Lactose	0.05 g	16.5 g	0.069 g	20.7 g	—	—	—	—	—	—
3	Croscarmellose sodium	0.01 g	3 g	0.026 g	7.8 g	—	—	—	—	—	—
4	Pregelatinized starch	0.02 g	6 g	0.02 g	6 g	0.002 g	0.6 g	0.0033 g	1 g	—	—
5	Mg-stearate	0.002 g	0.6 g	0.002 g	0.6 g	0.002 g	0.6 g	0.002 g	0.6 g	0.5 mg	0.15 g
6	Mais starch	—	—	—	—	0.002 g	0.6 g	0.06 g	18 g	61 mg	18.3 g
7	Na starch glycolate	—	—	—	—	0.002 g	0.6 g	0.02 g	6 g	—	—
8	Croscarmellose Na	—	—	—	—	0.002 g	0.6 g	0.02 g	6 g	—	—
9	Sucralose	—	—	—	—	0.002 g	0.6 g	0.003 g	0.9 g	3 mg	0.9 g
10	Lemon flavor	—	—	—	—	0.002 g	0.6 g	0.002 g	0.6 g	2 mg	0.6 g
11	Povidone	—	—	—	—	—	—	0.002 g	0.6 g	—	—
12	Aerosil 200	—	—	—	—	—	—	—	—	1 mg	0.3 g
13	Aerosil	—	—	—	—	—	—	—	—	1 mg	0.3 g
14	Flulac	—	—	—	—	—	—	—	—	10 mg	3 g
15	Dicalcium phosphate	—	—	—	—	—	—	—	—	40 mg	12 g
Total		0.09 g	27 g	0.12 g	36 g	0.1133 g	34 g	0.1153 g	34.6 g	107.5 mg	36.45 g