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Journal of Pharmaceutics
Volume 2017, Article ID 6081374, 9 pages
Research Article

Methanolic Extract of Dill Leaves Inhibits AGEs Formation and Shows Potential Hepatoprotective Effects in CCl4 Induced Liver Toxicity in Rat

1Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
3Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
4Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

Correspondence should be addressed to Mohammad Taghi Goodarzi; moc.oohay@izradoogtm

Received 23 July 2016; Revised 30 November 2016; Accepted 18 December 2016; Published 15 January 2017

Academic Editor: István Zupkó

Copyright © 2017 Ebrahim Abbasi Oshaghi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The research was aimed at evaluating the antiglycation, antioxidant, and hepatoprotective properties of methanolic extract of Anethum graveolens (dill). The antioxidant properties, photochemical characteristics, and antiglycation effects of dill extract were measured. Carbon tetrachloride-induced hepatotoxic rats were used to show the hepatoprotective activity of dill leaves. Different concentration of dill extract (0.032, 0.065, 0.125, 0.25, 0.5, and 1 mg/mL) showed potential antioxidant ability. The extract of dill leaves significantly reduced AGEs formation and also fructosamine and protein carbonyl levels in rats’ liver. Thiol groups’ oxidation, amyloid cross-β, and protein fragmentation () significantly reduced in treated rats. Liver damage markers significantly reduced in dill-treated animals (). Dill with potential antioxidant, antiglycation, and hepatoprotective effects can be suggested for treatment of diabetes complications.