Combined Effect of Synthetic and Natural Polymers in Preparation of Cetirizine Hydrochloride Oral Disintegrating Tablets: Optimization by Central Composite Design

Table 3

Formulation trial carried out for oral disintegrating tablet formulation of CTZ ODTs with CCS/ HRM at different level as per experimental design.

Trial run	Coded factor levels
	1		−1				−1
2		0				−1
3		1				−1
4		−1				0
5		0				0
6		1				0
7		−1				1
8		0				1
9		1				1
10		0				0
11		0				0
12		0				0
13		0				0
Translation coded values	−1			0			+1
: CCS (%)	2.5			5			7.5
: HRM (%)	5			10			15
Dependent variables
	Disintegration time (sec)
	Friability (%)
	Cumulative drug released at 25 minutes (%)