Journal of Pharmaceutics / 2017 / Article / Tab 7 / Research Article
Combined Effect of Synthetic and Natural Polymers in Preparation of Cetirizine Hydrochloride Oral Disintegrating Tablets: Optimization by Central Composite Design Table 7 Composition of the checkpoint formulations and the predicted and experimental values of response variables.
Number Croscarmellose sodium (mg) H. rosa-sinensis mucilage (mg)Response variables Observed response Predicted response Percentage error Avg Disintegration time 12.392 12.361 0.031 10.34 20.11 % friability 0.446 0.478 −0.032 2.231 Cumulative % drug released 100.031 100.367 −0.336 Disintegration time 12.932 12.834 0.763 9.13 17.36 % friability 0.511 0.496 3.024 1.008 Cumulative % drug released 100.64 99.986 0.654 Disintegration time 12.993 12.861 1.026 8.72 17.92 % friability 0.524 0.499 5.01 1.67 Cumulative % drug released 99.261 99.995 −0.734 Disintegration time 13.010 13.271 −1.96 9.05 16.04 % friability 0.500 0.498 0.401 0.133 Cumulative % drug released 99.523 99.768 −0.245 Disintegration time 13.323 13.445 −0.907 10.61 14.23 % friability 0.492 0.471 4.458 1.48 Cumulative % drug released 99.358 99.661 −0.304 Disintegration time 12.539 12.627 −0.696 10.40 16.71 % friability 0.515 0.482 6.846 2.282 Cumulative % drug released 100.364 100.092 0.272 Disintegration time 12.528 12.796 −2.094 12.14 15.49 % friability 0.498 0.467 6.638 0.212 Cumulative % drug released 100.548 100.161 0.386 Disintegration time 13.995 13.857 0.995 11.50 13.00 % friability 0.461 0.447 3.131 1.284 Cumulative % drug released 99.125 99.505 −0.381