Combined Effect of Synthetic and Natural Polymers in Preparation of Cetirizine Hydrochloride Oral Disintegrating Tablets: Optimization by Central Composite Design

Table 7

Composition of the checkpoint formulations and the predicted and experimental values of response variables.

Number	Croscarmellose sodium (mg)	H. rosa-sinensis mucilage (mg)	Response variables	Observed response	Predicted response	Percentage error	Avg
			Disintegration time	12.392	12.361	0.031
	10.34	20.11	% friability	0.446	0.478	−0.032	2.231
			Cumulative % drug released	100.031	100.367	−0.336
			Disintegration time	12.932	12.834	0.763
	9.13	17.36	% friability	0.511	0.496	3.024	1.008
			Cumulative % drug released	100.64	99.986	0.654
			Disintegration time	12.993	12.861	1.026
	8.72	17.92	% friability	0.524	0.499	5.01	1.67
			Cumulative % drug released	99.261	99.995	−0.734
			Disintegration time	13.010	13.271	−1.96
	9.05	16.04	% friability	0.500	0.498	0.401	0.133
			Cumulative % drug released	99.523	99.768	−0.245
			Disintegration time	13.323	13.445	−0.907
	10.61	14.23	% friability	0.492	0.471	4.458	1.48
			Cumulative % drug released	99.358	99.661	−0.304
			Disintegration time	12.539	12.627	−0.696
	10.40	16.71	% friability	0.515	0.482	6.846	2.282
			Cumulative % drug released	100.364	100.092	0.272
			Disintegration time	12.528	12.796	−2.094
	12.14	15.49	% friability	0.498	0.467	6.638	0.212
			Cumulative % drug released	100.548	100.161	0.386
			Disintegration time	13.995	13.857	0.995
	11.50	13.00	% friability	0.461	0.447	3.131	1.284
			Cumulative % drug released	99.125	99.505	−0.381