Research Article

Effect of Skin Model on In Vitro Performance of an Adhesive Dermally Applied Microarray Coated with Zolmitriptan

Table 1

Mass balance results, as percent of applied dose (%) of zolmitriptan into and through ex vivo human dermatomed skin and Strat-M membrane over 5 hours from a single application. Mean ± SE for skin (n=3 donors with 3 replicates/donor) and mean ± SD (6 replicates) for the membrane.

ParameterMean Zolmitriptan (%)
Dermatomed Skin
Mean Zolmitriptan (%)
Strat-M

Receptor 85.46 ± 1.3610.55 ± 6.15
Dermis 0.50 ± 0.04- - -
Epidermis 0.43 ± 0.16- - -
Stratum Corneum 0.13 ± 0.04- - -
Surface Wash 2.57 ± 1.09- - -
Strat-M Extraction- - - - 39.76 ± 19.75
Ti Array 3.27 ± 0.36 52.79 ± 29.28
Total Recovery92.35 ± 2.48103.1 ± 9.2