The Risk of Drug-Drug Interactions with Paracetamol in a Population of Hospitalized Geriatric Patients

Table 4

For the nine patients at risk, biochemical values, pDDIs with paracetamol, third-line pDDIs, and incidents during hospitalization that relates to pDDIs with paracetamol.

Patient case		1	2	3	4	5	6	7	8	9
Gender (F/M)		M	F	F	F	F	F	F	F	F
Age (years)		71	91	86	82	69	95	89	95	87
Biochemistry	Reference value
Hgb. (mmol/l)	M: 8.3–10.5 or F: 7.3–9.5	—	7.2	5.3	6.9	6.1	—	6.0	—	5.5
Leu. (x10^9/l)	3.5–8.8	17.4	—	10.0	10.3	11.5	11.9	13.2	—	—
eGFR (ml/min)	>60	—	43	36	—	—	59	53	41	27
ALAT (U/l)	M: 10–70 or F: 10–45	N/a	N/a	N/a	N/a	55	87	N/a	N/a	N/a
ASAT (U/l)	M: 15–45 or F:15–35	—	—	—	—	42	51	—	—	—
INR	<1, 2, or 2-3^A	—	3.5	3.8	1.7	—	3.2	4.6	—	—
Potential drug-drug interactions
pDDI1	Paracetamol and warfarin	+	+	+	+		+	+	+
pDDI2	Paracetamol and phenytoin					+
pDDI3	Paracetamol and valsartan									+
Number of third-line pDDIs with
	Warfarin	5	3	2	2		4	5	4
	Phenytoin					5
	Valsartan									1
Incidents at or during hospitalization^B
pDDI1	Bleeding or anaemia^C			+				+		+
pDDI2	Pain					+
	Hepatotoxicity					+
pDDI3	Tachycardia
	Hypertension									+

N/a = not available; — = if the value is within the reference value. The biochemical values mentioned are the most abnormal values during the hospitalization in the Department of Geriatric Medicine. Reference values are according to the mentioned value in OPUS. ^AThe treatment level during warfarin treatment with the indication of atrial fibrillation (given by sundhed.dk). ^BThe patient’s diagnose upon admission or did the patient experience any incidents during hospitalization that could relate to the pDDI with paracetamol (according to the outcomes described in the applied databases). ^CAnaemia is defined as haemoglobin 6.0 or less. pDDI = potential drug-drug interaction; third-line pDDIs: pDDIs with the same drug that is identified to have a pDDI with paracetamol; F = female; M = male; Hgb = haemoglobin; Leu = leucocytes; eGFR = estimated glomerular filtration rate; ALAT = alanine aminotransferase; ASAT = aspartate aminotransferase; INR = international normalized ratio; U = unit.