Table of Contents
Journal of Polymers
Volume 2015, Article ID 867928, 10 pages
http://dx.doi.org/10.1155/2015/867928
Research Article

Potential Application of a Visible Light-Induced Photocured Hydrogel Film as a Wound Dressing Material

1Department of Polymer and Color Engineering, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran 15916-34311, Iran
2Department of Drug and Food Control, Faculty of Pharmacy and Biotechnology Research Center, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran 14176-14411, Iran
3Department of Science, Iran Polymer and Petrochemical Institute, P.O. Box 14965-115, Tehran 14977-13115, Iran
4Department of Novel Drug Delivery Systems, Iran Polymer and Petrochemical Institute, P.O. Box 14965-115, Tehran 14977-13115, Iran

Received 29 May 2015; Revised 9 August 2015; Accepted 11 August 2015

Academic Editor: Iliya Rashkov

Copyright © 2015 Aazadehsadat Hashemi Doulabi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The objective of this work was to prepare hydrogel films, as semi-interpenetrating polymer networks (semi-IPN), based on polyethylene glycol-co-fumarate (PEGF) and chitosan (Ch) blends. Hydrogel films were prepared by free radical cross-linking of PEGF, an unsaturated aliphatic polyester, in the presence of N-vinyl pyrrolidone (NVP), camphorquinone (CQ), and N,N-dimethyl-p-toluidine (DMPT) as a cross-linking, photoinitiating, and accelerating agent, respectively. The effect of NVP concentration on physicochemical and biological properties of semi-IPN film properties was evaluated. The sol fraction, water vapor transmission rate, and swelling degree of the hydrogel films were also investigated. Antibacterial activity against S. aureus was observed for the photocured blend hydrogels of Ch/PEGF with no toxicity to L929 cells according to the cell viability assays. Blend hydrogel films showing 600 ± 88% of equilibrium swelling degree in water and the lowest sol fraction (3.14 ± 1.22%) were obtained at 20 wt% of NVP content whilst preserving their own cytocompatibility and antibacterial activity. Therefore, this formulation was considered as an optimal semi-IPN blend hydrogel film composition with potential application for wound dressing.