Research Article

A Theoretical Study of the Relationships between Electronic Structure and CB1 and CB2 Cannabinoid Receptor Binding Affinity in a Group of 1-Aryl-5-(1-H-pyrrol-1-yl)-1-H-pyrazole-3-carboxamides

Table 7

Beta coefficients and t-test for significance of coefficients in (12).

Beta (12) -level

(LUMO)*0.7013.290.0000001
(LUMO + 1)*0.355.750.0001
(LUMO + 2)*−0.48−8.640.000003
(LUMO + 2)*−0.20−3.540.005
−0.17−3.180.009