Late Toxicities after Conventional Radiotherapy for Nasopharyngeal Carcinoma: Incidence and Risk Factors

Table 4

Uni- and multivariate analyses of late toxicity risk factors.

Late toxicity	Univariate analysis		Multivariate analysis
	Factor	𝑃 value	Factor	𝑃 value	HR/CI
Dental damages	Initial dental hygiene	0.0001	Initial dental hygiene	0.0001	0.47 (0.33–0.68)
	Gender	0.02
	Chemotherapy	0.03
Trismus	T Stage	0.01	—
	Age	0.01	Age	0.01	0.57 (0.36–0.89)
	Gender	0.0001	Gender	0.0001	2.25 (1.53–3.)
Neck fibrosis	N Stage	0.0001	N Sage	0.0001	1.34 (1.14–1.59)
	Gender	0.006	—
	Chemotherapy	0.001	—
Hearing impairment	Gender	0.0001	Gender	0.001	1.78 (1.25–2.54)
	Total dose	0.02	Total dose	0.02	0.64 (0.44–0.94)
Neurotoxicity	Age	0.04	—
	Radiotherapy modality	0.02	—
Endocrine dysfunction	Age	0.002	—
	Gender	0.04	—
Osteoradionecrosis	Initial dental hygiene	0.04	—
	Dental mobility	0.04

Abbreviations: HR: Hazard Ratio; CI: Confidence Interval.