Repeat Whole Brain Radiation Therapy with a Simultaneous Infield Boost: A Novel Technique for Reirradiation

Table 1

Patient characteristics (N = 16).

Age	55 (24–73)
Sex
Male	7
Female	9
Race
White	11
AA	5
Primary histology
NSCLC	5
Breast	5
Small cell lung	4
Melanoma	1
Adenocarcinoma	1
KPS (at time of repeat WB-SIB)
90	5
80	5
70	1
<70	5
RPA class (at time of repeat WB-SIB)
I	3
II	8
III	5
Median Graded Prognostic Index (GPA)	1
Median number of lesions (at time of repeat WB-SIB)	9 (7–47)
Total number of boosted lesions	202
Use of steroids during the course of repeat WB-SIB	16/16
Median PTV volume (for repeat WB-SIB)	21.84 cm^3 (3.66–236.2)
Median time from initial WBRT to repeat WB-SIB (days)	339.5 (97–1895)
Systemic disease status at time of repeat WB-SIB
Progressive	3
Stable	13
Median clinical follow-up	77.0 days
Clinical outcome
Improved	7
Stable	6
Declined	2
Median imaging follow-up	42.5 days

WB-SIB: whole brain simultaneous infield boost, KPS: Karnofsky Performance Status, WBRT: whole brain radiation therapy, OS: overall survival, RPA: recursive partitioning analysis, and NSCLC: non-small-cell lung cancer.