Table of Contents
Journal of Radiotherapy
Volume 2014, Article ID 489824, 13 pages
http://dx.doi.org/10.1155/2014/489824
Review Article

Stereotactic Hypofractionated Irradiation for Metastatic, Inoperable, and Recurrent Malignancies: A Modern Necessity, rather than a Luxury

Department of RT, HealthCare Global, Bangalore Institute of Oncology, Bengaluru, Karnataka 560027, India

Received 28 September 2014; Revised 6 December 2014; Accepted 9 December 2014; Published 28 December 2014

Academic Editor: Oliver Micke

Copyright © 2014 Sridhar P. Susheela et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. F. Fowler, W. A. Tomé, J. D. Fenwick, and M. P. Mehta, “A challenge to traditional radiation oncology,” International Journal of Radiation Oncology, Biology, Physics, vol. 60, no. 4, pp. 1241–1256, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. J. F. Fowler, “21 years of biologically effective dose,” British Journal of Radiology, vol. 83, no. 991, pp. 554–568, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Park, L. Papiez, S. Zhang, M. Story, and R. D. Timmerman, “Universal survival curve and single fraction equivalent dose: useful tools in understanding potency of ablative radiotherapy,” International Journal of Radiation Oncology Biology Physics, vol. 70, no. 3, pp. 847–852, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. H. D. Thames Jr., H. R. Withers, L. J. Peters, and G. H. Fletcher, “Changes in early and late radiation responses with altered dose fractionation: implications for dose-survival relationships,” International Journal of Radiation Oncology Biology Physics, vol. 8, no. 2, pp. 219–226, 1982. View at Publisher · View at Google Scholar · View at Scopus
  5. B. Jones, L. T. Tan, and R. G. Dale, “Derivation of the optimum dose per fraction from the linear quadratic model,” British Journal of Radiology, vol. 68, no. 812, pp. 894–902, 1995. View at Publisher · View at Google Scholar · View at Scopus
  6. J. F. Fowler, “Fractionated radiation therapy after Strandqvist,” Acta Radiologica Oncology, vol. 23, no. 4, pp. 209–216, 1984. View at Publisher · View at Google Scholar · View at Scopus
  7. M. V. Williams, J. Denekamp, and J. F. Fowler, “A review of alpha/beta ratios for experimental tumors : implications for clinical studies of altered fractionation,” International Journal of Radiation Oncology, Biology, Physics, vol. 11, pp. 87–96, 1985. View at Publisher · View at Google Scholar
  8. E. H. Balagamwala, S. T. Chao, and J. H. Suh, “Principles of radiobiology of stereotactic radiosurgery and clinical applications in the central nervous system,” Technology in Cancer Research and Treatment, vol. 11, no. 1, pp. 3–13, 2012. View at Google Scholar · View at Scopus
  9. H. Blomgren, I. Lax, I. Naslund, and R. Svanstrom, “Stereotactic high dose fraction radiation therapy of extracranial tumors using an accelerator. Clinical experience of the first thirty-one patients,” Acta Oncologica, vol. 34, no. 6, pp. 861–870, 1995. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Ayadi, C. Ginestet, F. Gassa, L. Claude, and J.-J. Mazeron, “Linac-based stereotactic radiosurgery and radiotherapy,” Bulletin du Cancer, vol. 97, no. 7, pp. 791–806, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. B. W. Loo, J. Y. Chang, L. A. Dawson et al., “Stereotactic ablative radiotherapy: what's in a name?” Practical Radiation Oncology, vol. 1, no. 1, pp. 38–39, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. K. R. Trott, “Experimental results and clinical implications of the four R's in fractionated radiotherapy,” Radiation and Environmental Biophysics, vol. 20, no. 3, pp. 159–170, 1982. View at Publisher · View at Google Scholar · View at Scopus
  13. I. Corre, C. Niaudet, and F. Paris, “Plasma membrane signaling induced by ionizing radiation,” Mutation Research—Reviews in Mutation Research, vol. 704, no. 1–3, pp. 61–67, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Lee, S. L. Auh, Y. Wang et al., “Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment,” Blood, vol. 114, no. 3, pp. 589–595, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Y. Almaghrabi, S. Supiot, F. Paris, M.-A. Mahé, and E. Rio, “Stereotactic body radiation therapy for abdominal oligometastases: a biological and clinical review,” Radiation Oncology, vol. 7, no. 1, article 126, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. S. E. Finkelstein, R. Timmerman, W. H. McBride et al., “The confluence of stereotactic ablative radiotherapy and tumor immunology,” Clinical and Developmental Immunology, vol. 2011, Article ID 439752, 7 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. S. S. Lo, A. J. Fakiris, E. L. Chang et al., “Stereotactic body radiation therapy: a novel treatment modality,” Nature Reviews Clinical Oncology, vol. 7, no. 1, pp. 44–54, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. F. Pajonk, E. Vlashi, and W. H. McBride, “Radiation resistance of cancer stem cells: the 4 R's of radiobiology revisited,” Stem Cells, vol. 28, no. 4, pp. 639–648, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. H. J. Park, R. J. Griffin, S. Hui, S. H. Levitt, and C. W. Song, “Radiation-induced vascular damage in tumors: implications of vascular damage in ablative hypofractionated radiotherapy (SBRT and SRS),” Radiation Research, vol. 177, no. 3, pp. 311–327, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. E. Touboul and M. Schlienger, “Radiotherapeutic basis of radiosurgery as applied to cerebral arteriovenous malformations: dose-volume effects,” Neurochirurgie, vol. 47, no. 2-3, pp. 212–220, 2001. View at Google Scholar · View at Scopus
  21. M. Kocher, H. Treuer, J. Voges, M. Hoevels, V. Sturm, and R.-P. Müller, “Computer simulation of cytotoxic and vascular effects of radiosurgery in solid and necrotic brain metastases,” Radiotherapy and Oncology, vol. 54, no. 2, pp. 149–156, 2000. View at Publisher · View at Google Scholar · View at Scopus
  22. M. T. Milano, A. W. Katz, H. Zhang, and P. Okunieff, “Oligometastases treated with stereotactic body radiotherapy: long-term follow-up of prospective study,” International Journal of Radiation Oncology, Biology, Physics, vol. 83, no. 3, pp. 878–886, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. M. T. Milano, A. W. Katz, A. G. Muhs et al., “A prospective pilot study of curative-intent stereotactic body radiation therapy in patients with 5 or fewer oligometastatic lesions,” Cancer, vol. 112, no. 3, pp. 650–658, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. B. M. Künzli, P. Abitabile, and C. A. Maurer, “Radiofrequency ablation of liver tumors: actual limitations and potential solutions in the future,” World Journal of Hepatology, vol. 3, no. 1, pp. 8–14, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. T. F. Wood, D. M. Rose, M. Chung, D. P. Allegra, L. J. Foshag, and A. J. Bilchik, “Radiofrequency ablation of 231 unresectable hepatic tumors: Indications, limitations, and complications,” Annals of Surgical Oncology, vol. 7, no. 8, pp. 593–600, 2000. View at Publisher · View at Google Scholar · View at Scopus
  26. C. M. Faul and J. C. Flickinger, “The use of radiation in the management of spinal metastases,” Journal of Neuro-Oncology, vol. 23, no. 2, pp. 149–161, 1995. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Yamada, M. H. Bilsky, D. M. Lovelock et al., “High-dose, single-fraction image-guided intensity-modulated radiotherapy for metastatic spinal lesions,” International Journal of Radiation Oncology, Biology, Physics, vol. 71, no. 2, pp. 484–490, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. E. L. Chang, A. S. Shiu, E. Mendel et al., “Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure,” Journal of Neurosurgery: Spine, vol. 7, no. 2, pp. 151–160, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. B. Gill, E. Oermann, A. Ju et al., “Fiducial-free CyberKnife stereotactic body radiation therapy for single vertebral body metastases: acceptable local control and normal tissue tolerance with five-fraction approach,” Frontiers in Oncology, vol. 2, article 39, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. R. J. Amdur, J. Bennett, K. Olivier et al., “A Prospective, phase II study demonstrating the potential value and limitation of radiosurgery for spine metastases,” The American Journal of Clinical Oncology, vol. 32, no. 5, pp. 515–520, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Ryu, R. Jin, J.-Y. Jin et al., “Pain control by image-guided radiosurgery for solitary spinal metastasis,” Journal of Pain and Symptom Management, vol. 35, no. 3, pp. 292–298, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Ryu, S. L. Pugh, P. C. Gerszten et al., “RTOG 0631 phase 2/3 study of image guided stereotactic radiosurgery for localized (1–3) spine metastases: phase 2 results,” Practical Radiation Oncology, vol. 4, no. 2, pp. 76–81, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. P. C. Gerszten, S. A. Burton, C. Ozhasoglu, and W. C. Welch, “Radiosurgery for spinal metastases: clinical experience in 500 cases from a single institution,” Spine, vol. 32, no. 2, pp. 193–199, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Milker-Zabel, A. Zabel, C. Thilmann, W. Schlegel, M. Wannenmacher, and J. Debus, “Clinical results of retreatment of vertebral bone metastases by stereotactic conformal radiotherapy and intensity-modulated radiotherapy,” International Journal of Radiation Oncology, Biology, Physics, vol. 55, no. 1, pp. 162–167, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. H. D. Moulding, J. B. Elder, E. Lis et al., “Local disease control after decompressive surgery and adjuvant high-dose single-fraction radiosurgery for spine metastases,” Journal of Neurosurgery: Spine, vol. 13, no. 1, pp. 87–93, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. S. Sohn and C. K. Chung, “The role of stereotactic radiosurgery in metastasis to the spine,” Journal of Korean Neurosurgical Society, vol. 51, no. 1, pp. 1–7, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. M. E. Linskey, D. W. Andrews, A. L. Asher et al., “The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline,” Journal of Neuro-Oncology, vol. 96, no. 1, pp. 45–68, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. C. G. Patil, K. Pricola, J. M. Sarmiento, S. K. Garg, A. Bryant, and K. L. Black, “Whole brain radiation therapy (WBRT) alone versus WBRT and radiosurgery for the treatment of brain metastases,” Cochrane Database of Systematic Reviews, vol. 9, Article ID CD006121, 2012. View at Google Scholar · View at Scopus
  39. D. W. Andrews, C. B. Scott, P. W. Sperduto et al., “Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial,” The Lancet, vol. 363, no. 9422, pp. 1665–1672, 2004. View at Publisher · View at Google Scholar · View at Scopus
  40. H. Aoyama, H. Shirato, M. Tago et al., “Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial,” Journal of the American Medical Association, vol. 295, no. 21, pp. 2483–2491, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Kocher, R. Soffietti, U. Abacioglu et al., “Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study,” Journal of Clinical Oncology, vol. 29, no. 2, pp. 134–141, 2011. View at Publisher · View at Google Scholar · View at Scopus
  42. M. Yamamoto, T. Serizawa, T. Shuto et al., “Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study,” The Lancet Oncology, vol. 15, no. 4, pp. 387–395, 2014. View at Publisher · View at Google Scholar · View at Scopus
  43. E. L. Chang, J. S. Wefel, K. R. Hess et al., “Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial,” The Lancet Oncology, vol. 10, no. 11, pp. 1037–1044, 2009. View at Publisher · View at Google Scholar · View at Scopus
  44. G. S. Gazelle, M. G. M. Hunink, K. M. Kuntz et al., “Cost-effectiveness of hepatic metastasectomy in patients with metastatic colorectal carcinoma: a state-transition Monte Carlo decision analysis,” Annals of Surgery, vol. 237, no. 4, pp. 544–555, 2003. View at Publisher · View at Google Scholar · View at Scopus
  45. J. Scheele and A. Altendorf-Hofmann, “Resection of colorectal liver metastases,” Langenbeck's Archives of Surgery, vol. 384, no. 4, pp. 313–327, 1999. View at Publisher · View at Google Scholar · View at Scopus
  46. R. T.-P. Poon, S.-T. Fan, F. H.-F. Tsang, and J. Wong, “Locoregional therapies for hepatocellular carcinoma: a critical review from the surgeon's perspective,” Annals of Surgery, vol. 235, no. 4, pp. 466–486, 2002. View at Publisher · View at Google Scholar · View at Scopus
  47. D. Ansari and R. Andersson, “Radiofrequency ablation or percutaneous ethanol injection for the treatment of liver tumors,” World Journal of Gastroenterology, vol. 18, no. 10, pp. 1003–1008, 2012. View at Publisher · View at Google Scholar · View at Scopus
  48. G. Germani, M. Pleguezuelo, K. Gurusamy, T. Meyer, G. Isgrò, and A. K. Burroughs, “Clinical outcomes of radiofrequency ablation, percutaneous alcohol and acetic acid injection for hepatocelullar carcinoma: a meta-analysis,” Journal of Hepatology, vol. 52, no. 3, pp. 380–388, 2010. View at Publisher · View at Google Scholar · View at Scopus
  49. A. Townsend, T. Price, and C. Karapetis, “Selective internal radiation therapy for liver metastases from colorectal cancer,” Cochrane Database of Systematic Reviews, vol. 4, Article ID CD007045, 2009. View at Google Scholar
  50. K. E. Rusthoven, B. D. Kavanagh, H. Cardenes et al., “Multi-institutional phase I/II trial of stereotactic body radiation therapy for liver metastases,” Journal of Clinical Oncology, vol. 27, no. 10, pp. 1572–1578, 2009. View at Publisher · View at Google Scholar · View at Scopus
  51. R. Lanciano, J. Lamond, J. Yang et al., “Stereotactic body radiation therapy for patients with heavily pretreated liver metastases and liver tumors,” Frontiers in Oncology, vol. 2, article 23, 2012. View at Publisher · View at Google Scholar · View at Scopus
  52. G. Ambrosino, F. Polistina, G. Costantin et al., “Image-guided robotic stereotactic radiosurgery for unresectable liver metastases: preliminary results,” Anticancer Research, vol. 29, no. 8, pp. 3381–3384, 2009. View at Google Scholar · View at Scopus
  53. M. T. Lee, J. J. Kim, R. Dinniwell et al., “Phase I study of individualized stereotactic body radiotherapy of liver metastases,” Journal of Clinical Oncology, vol. 27, no. 10, pp. 1585–1591, 2009. View at Publisher · View at Google Scholar · View at Scopus
  54. A. W. Katz, M. Carey-Sampson, A. G. Muhs, M. T. Milano, M. C. Schell, and P. Okunieff, “Hypofractionated stereotactic body radiation therapy (SBRT) for limited hepatic metastases,” International Journal of Radiation Oncology Biology Physics, vol. 67, no. 3, pp. 793–798, 2007. View at Publisher · View at Google Scholar · View at Scopus
  55. A. E. M. van der Pool, A. M. Romero, W. Wunderink et al., “Stereotactic body radiation therapy for colorectal liver metastases,” British Journal of Surgery, vol. 97, no. 3, pp. 377–382, 2010. View at Publisher · View at Google Scholar · View at Scopus
  56. P. Okunieff, A. L. Petersen, A. Philip et al., “Stereotactic Body Radiation Therapy (SBRT) for lung metastases,” Acta Oncologica, vol. 45, no. 7, pp. 808–817, 2006. View at Publisher · View at Google Scholar · View at Scopus
  57. K. E. Rusthoven, B. D. Kavanagh, S. H. Burri et al., “Multi-institutional phase I/II trial of stereotactic body radiation therapy for lung metastases,” Journal of Clinical Oncology, vol. 27, no. 10, pp. 1579–1584, 2009. View at Publisher · View at Google Scholar · View at Scopus
  58. Y. Norihisa, Y. Nagata, K. Takayama et al., “Stereotactic body radiotherapy for oligometastatic lung tumors,” International Journal of Radiation Oncology Biology Physics, vol. 72, no. 2, pp. 398–403, 2008. View at Publisher · View at Google Scholar · View at Scopus
  59. M. Joyner, B. J. Salter, N. Papanikolaou, and M. Fuss, “Stereotactic body radiation therapy for centrally located lung lesions,” Acta Oncologica, vol. 45, no. 7, pp. 802–807, 2006. View at Publisher · View at Google Scholar · View at Scopus
  60. Y. Zhang, J. P. Xiao, H. Z. Zhang et al., “Stereotactic body radiation therapy favors long-term overall survival in patients with lung metastases: five-year experience of a single-institution,” Chinese Medical Journal, vol. 124, no. 24, pp. 4132–4137, 2011. View at Publisher · View at Google Scholar · View at Scopus
  61. S. H. Bae, M.-S. Kim, C. K. Cho et al., “High dose stereotactic body radiotherapy using three fractions for colorectal oligometastases,” Journal of Surgical Oncology, vol. 106, no. 2, pp. 138–143, 2012. View at Publisher · View at Google Scholar · View at Scopus
  62. C. W. Choi, C. K. Cho, S. Y. Yoo et al., “Image-guided stereotactic body radiation therapy in patients with isolated para -aortic lymph node metastases from uterine cervical and corpus cancer,” International Journal of Radiation Oncology Biology Physics, vol. 74, no. 1, pp. 147–153, 2009. View at Publisher · View at Google Scholar · View at Scopus
  63. M. Bignardi, P. Navarria, P. Mancosu et al., “Clinical outcome of hypofractionated stereotactic radiotherapy for abdominal lymph node metastases,” International Journal of Radiation Oncology Biology Physics, vol. 81, no. 3, pp. 831–838, 2011. View at Publisher · View at Google Scholar · View at Scopus
  64. B. A. Jereczek-Fossa, G. Beltramo, L. Fariselli et al., “Robotic image-guided stereotactic radiotherapy, for isolated recurrent primary, lymph node or metastatic prostate cancer,” International Journal of Radiation Oncology, Biology, Physics, vol. 82, no. 2, pp. 889–897, 2012. View at Publisher · View at Google Scholar · View at Scopus
  65. J. Torok, R. E. Wegner, S. A. Burton, and D. E. Heron, “Stereotactic body radiation therapy for adrenal metastases: a retrospective review of a noninvasive therapeutic strategy,” Future Oncology, vol. 7, no. 1, pp. 145–151, 2011. View at Publisher · View at Google Scholar · View at Scopus
  66. M. Scorsetti, F. Alongi, A. R. Filippi et al., “Long-term local control achieved after hypofractionated stereotactic body radiotherapy for adrenal gland metastases: a retrospective analysis of 34 patients,” Acta Oncologica, vol. 51, no. 5, pp. 618–623, 2012. View at Publisher · View at Google Scholar · View at Scopus
  67. S. Cykert, P. Dilworth-Anderson, M. H. Monroe et al., “Factors associated with decisions to undergo surgery among patients with newly diagnosed early-stage lung cancer,” Journal of the American Medical Association, vol. 303, no. 23, pp. 2368–2376, 2010. View at Publisher · View at Google Scholar · View at Scopus
  68. Ö. Birim, A. P. Kappetein, and A. J. J. C. Bogers, “Charlson comorbidity index as a predictor of long-term outcome after surgery for nonsmall cell lung cancer,” European Journal of Cardio-thoracic Surgery, vol. 28, no. 5, pp. 759–762, 2005. View at Publisher · View at Google Scholar · View at Scopus
  69. J. P. Wisnivesky, M. Bonomi, C. Henschke, M. Iannuzzi, and T. McGinn, “Radiation therapy for the treatment of unresected stage I-II non-small cell lung cancer,” Chest, vol. 128, no. 3, pp. 1461–1467, 2005. View at Publisher · View at Google Scholar · View at Scopus
  70. F. J. Lagerwaard, N. E. Verstegen, C. J. A. Haasbeek et al., “Outcomes of stereotactic ablative radiotherapy in patients with potentially operable stage i non-small cell lung cancer,” International Journal of Radiation Oncology, Biology, Physics, vol. 83, no. 1, pp. 348–353, 2012. View at Publisher · View at Google Scholar · View at Scopus
  71. O. S. H. Chan, R. M. W. Yeung, A. W. M. Hung et al., “Stereotactic ablative radiotherapy for medically inoperable early stage lung cancer: early outcomes,” Hong Kong Medical Journal, vol. 18, no. 5, pp. 412–418, 2012. View at Google Scholar · View at Scopus
  72. C. J. A. Haasbeek, F. J. Lagerwaard, B. J. Slotman, and S. Senan, “Outcomes of stereotactic ablative radiotherapy for centrally located early-stage lung cancer,” Journal of Thoracic Oncology, vol. 6, no. 12, pp. 2036–2043, 2011. View at Publisher · View at Google Scholar · View at Scopus
  73. A. J. Fakiris, R. C. McGarry, C. T. Yiannoutsos et al., “Stereotactic body radiation therapy for early-stage non-small-cell lung carcinoma: four-year results of a prospective phase II study,” International Journal of Radiation Oncology, Biology, Physics, vol. 75, no. 3, pp. 677–682, 2009. View at Publisher · View at Google Scholar · View at Scopus
  74. H. Bilal, S. Mahmood, B. Rajashanker, and R. Shah, “Is radiofrequency ablation more effective than stereotactic ablative radiotherapy in patients with early stage medically inoperable non-small cell lung cancer?” Interactive Cardiovascular and Thoracic Surgery, vol. 15, no. 2, pp. 258–265, 2012. View at Publisher · View at Google Scholar · View at Scopus
  75. R. Timmerman, R. Paulus, J. Galvin et al., “Stereotactic body radiation therapy for inoperable early stage lung cancer,” The Journal of the American Medical Association, vol. 303, no. 11, pp. 1070–1076, 2010. View at Publisher · View at Google Scholar · View at Scopus
  76. C. Sun, D. Ansari, R. Andersson, and D.-Q. Wu, “Does gemcitabine-based combination therapy improve the prognosis of unresectable pancreatic cancer?” World Journal of Gastroenterology, vol. 18, no. 35, pp. 4944–4958, 2012. View at Publisher · View at Google Scholar · View at Scopus
  77. D. R. Xie, H. L. Liang, Y. Wang, S. S. Guo, and Q. Yang, “Meta-analysis on inoperable pancreatic cancer: a comparison between gemcitabine-based combination therapy and gemcitabine alone,” World Journal of Gastroenterology, vol. 12, no. 43, pp. 6973–6981, 2006. View at Google Scholar · View at Scopus
  78. J.-K. Kang, M.-S. Kim, C. K. Cho et al., “Stereotactic body radiation therapy for inoperable hepatocellular carcinoma as a local salvage treatment after incomplete transarterial chemoembolization,” Cancer, vol. 118, no. 21, pp. 5424–5431, 2012. View at Publisher · View at Google Scholar · View at Scopus
  79. J. K. O'Connor, J. Trotter, G. L. Davis, J. Dempster, G. B. Klintmalm, and R. M. Goldstein, “Long-term outcomes of stereotactic body radiation therapy in the treatment of hepatocellular cancer as a bridge to transplantation,” Liver Transplantation, vol. 18, no. 8, pp. 949–954, 2012. View at Publisher · View at Google Scholar · View at Scopus
  80. D. L. Andolino, C. S. Johnson, M. Maluccio et al., “Stereotactic body radiotherapy for primary hepatocellular carcinoma,” International Journal of Radiation Oncology Biology Physics, vol. 81, no. 4, pp. e447–e453, 2011. View at Publisher · View at Google Scholar · View at Scopus
  81. R. A. Ibarra, D. Rojas, L. Snyder et al., “Multicenter results of stereotactic body radiotherapy (SBRT) for non-resectable primary liver tumors,” Acta Oncologica, vol. 51, no. 5, pp. 575–583, 2012. View at Publisher · View at Google Scholar · View at Scopus
  82. C. Sandroussi, L. A. Dawson, M. Lee et al., “Radiotherapy as a bridge to liver transplantation for hepatocellular carcinoma,” Transplant International, vol. 23, no. 3, pp. 299–306, 2010. View at Publisher · View at Google Scholar · View at Scopus
  83. D. T. Chang, D. Schellenberg, J. Shen et al., “Stereotactic radiotherapy for unresectable adenocarcinoma of the pancreas,” Cancer, vol. 115, no. 3, pp. 665–672, 2009. View at Publisher · View at Google Scholar · View at Scopus
  84. J. C. M. Rwigema, D. E. Heron, S. D. Parikh et al., “Adjuvant stereotactic body radiotherapy for resected pancreatic adenocarcinoma with close or positive margins,” Journal of Gastrointestinal Cancer, vol. 43, no. 1, pp. 70–76, 2012. View at Publisher · View at Google Scholar · View at Scopus
  85. D. Schellenberg, J. Kim, C. Christman-Skieller et al., “Single-fraction stereotactic body radiation therapy and sequential gemcitabine for the treatment of locally advanced pancreatic cancer,” International Journal of Radiation Oncology, Biology, Physics, vol. 81, no. 1, pp. 181–188, 2011. View at Publisher · View at Google Scholar · View at Scopus
  86. B. M. Barney, K. R. Olivier, R. C. Miller, and M. G. Haddock, “Clinical outcomes and toxicity using Stereotactic Body Radiotherapy (SBRT) for advanced cholangiocarcinoma,” Radiation Oncology, vol. 7, no. 1, article no. 67, 2012. View at Publisher · View at Google Scholar · View at Scopus
  87. F. A. Polistina, R. Guglielmi, C. Baiocchi et al., “Chemoradiation treatment with gemcitabine plus stereotactic body radiotherapy for unresectable, non-metastatic, locally advanced hilar cholangiocarcinoma. Results of a five year experience,” Radiotherapy and Oncology, vol. 99, no. 2, pp. 120–123, 2011. View at Publisher · View at Google Scholar · View at Scopus
  88. G. De Meerleer, V. Khoo, B. Escudier et al., “Radiotherapy for renal-cell carcinoma,” The Lancet Oncology, vol. 15, no. 4, pp. e170–e177, 2014. View at Publisher · View at Google Scholar · View at Scopus
  89. P. J. Wersäll, H. Blomgren, I. Lax et al., “Extracranial stereotactic radiotherapy for primary and metastatic renal cell carcinoma,” Radiotherapy and Oncology, vol. 77, no. 1, pp. 88–95, 2005. View at Publisher · View at Google Scholar · View at Scopus
  90. J. J. Beitler, D. Makara, P. Silverman, and G. Lederman, “Definitive, high-dose-per-fraction, conformal, stereotactic external radiation for renal cell carcinoma,” American Journal of Clinical Oncology, vol. 27, no. 6, pp. 646–648, 2004. View at Publisher · View at Google Scholar · View at Scopus
  91. C. Svedman, K. Karlsson, E. Rutkowska et al., “Stereotactic body radiotherapy of primary and metastatic renal lesions for patients with only one functioning kidney,” Acta Oncologica, vol. 47, no. 8, pp. 1578–1583, 2008. View at Publisher · View at Google Scholar · View at Scopus
  92. S. Siva, D. Pham, S. Gill, N. M. Corcoran, and F. Foroudi, “A systematic review of stereotactic radiotherapy ablation for primary renal cell carcinoma,” BJU International, vol. 110, no. 11 B, pp. E737–E743, 2012. View at Publisher · View at Google Scholar · View at Scopus
  93. P. M. L. Teo, W. H. Kwan, A. T. C. Chan, W. Y. Lee, W. W. K. King, and C. O. Mok, “How successful is high-dose (≤60 Gy) reirradiation using mainly external beams in salvaging local failures of nasopharyngeal carcinoma?” International Journal of Radiation Oncology Biology Physics, vol. 40, no. 4, pp. 897–913, 1998. View at Publisher · View at Google Scholar · View at Scopus
  94. C. Suárez, J. P. Rodrigo, A. Rinaldo, J. A. Langendijk, A. R. Shaha, and A. Ferlito, “Current treatment options for recurrent nasopharyngeal cancer,” European Archives of Oto-Rhino-Laryngology, vol. 267, no. 12, pp. 1811–1824, 2010. View at Publisher · View at Google Scholar · View at Scopus
  95. G. Ozyigit, M. Cengiz, G. Yazici et al., “A retrospective comparison of robotic stereotactic body radiotherapy and three-dimensional conformal radiotherapy for the reirradiation of locally recurrent nasopharyngeal carcinoma,” International Journal of Radiation Oncology, Biology, Physics, vol. 81, no. 4, pp. e263–e268, 2011. View at Publisher · View at Google Scholar · View at Scopus
  96. H. Iwata, K. Tatewaki, M. Inoue, N. Yokota, K. Sato, and Y. Shibamoto, “Salvage stereotactic reirradiation using the CyberKnife for the local recurrence of nasal or paranasal carcinoma,” Radiotherapy and Oncology, vol. 104, no. 3, pp. 355–360, 2012. View at Publisher · View at Google Scholar · View at Scopus
  97. S. Dewas, J. E. Bibault, X. Mirabel et al., “Robotic image-guided reirradiation of lateral pelvic recurrences: preliminary results,” Radiation Oncology, vol. 6, no. 1, p. 77, 2011. View at Publisher · View at Google Scholar · View at Scopus
  98. A. Sahgal, C. Ames, D. Chou et al., “Stereotactic body radiotherapy is effective salvage therapy for patients with prior radiation of spinal metastases,” International Journal of Radiation Oncology Biology Physics, vol. 74, no. 3, pp. 723–731, 2009. View at Publisher · View at Google Scholar · View at Scopus
  99. C. Y. H. Choi, J. R. Adler, I. C. Gibbs et al., “Stereotactic radiosurgery for treatment of spinal metastases recurring in close proximity to previously irradiated spinal cord,” International Journal of Radiation Oncology Biology Physics, vol. 78, no. 2, pp. 499–506, 2010. View at Publisher · View at Google Scholar · View at Scopus
  100. F. Sterzing, H. Hauswald, M. Uhl et al., “Spinal cord sparing reirradiation with helical tomotherapy,” Cancer, vol. 116, no. 16, pp. 3961–3968, 2010. View at Publisher · View at Google Scholar · View at Scopus
  101. A. K. Garg, X.-S. Wang, A. S. Shiu et al., “Prospective evaluation of spinal reirradiation by using stereotactic body radiation therapy: the university of Texas MD Anderson cancer center experience,” Cancer, vol. 117, no. 15, pp. 3509–3516, 2011. View at Publisher · View at Google Scholar · View at Scopus
  102. U.-K. Chang, W.-I. Cho, M.-S. Kim, C. K. Cho, D. H. Lee, and C. H. Rhee, “Local tumor control after retreatment of spinal metastasis using stereotactic body radiotherapy; comparison with initial treatment group,” Acta Oncologica, vol. 51, no. 5, pp. 589–595, 2012. View at Publisher · View at Google Scholar · View at Scopus
  103. A. Mahadevan, S. Floyd, E. Wong, S. Jeyapalan, M. Groff, and E. Kasper, “Stereotactic body radiotherapy reirradiation for recurrent epidural spinal metastases,” International Journal of Radiation Oncology Biology Physics, vol. 81, no. 5, pp. 1500–1505, 2011. View at Publisher · View at Google Scholar · View at Scopus
  104. A. W. Blackstock and R. Govindan, “Definitive chemoradiation for the treatment of locally advanced non-small-cell lung cancer,” Journal of Clinical Oncology, vol. 25, no. 26, pp. 4146–4152, 2007. View at Publisher · View at Google Scholar · View at Scopus
  105. E. L. Gressen, M. Werner-Wasik, J. Cohn, A. Topham, and W. J. Curran Jr., “Thoracic reirradiation for symptomatic relief after prior radiotherapeutic management for lung cancer,” American Journal of Clinical Oncology, vol. 23, no. 2, pp. 160–163, 2000. View at Publisher · View at Google Scholar · View at Scopus
  106. I. M. Poltinnikov, K. Fallon, Y. Xiao, J. E. Reiff, W. J. Curran Jr., and M. Werner-Wasik, “Combination of longitudinal and circumferential three-dimensional esophageal dose distribution predicts acute esophagitis in hypofractionated reirradiation of patients with non-small-cell lung cancer treated in stereotactic body frame,” International Journal of Radiation Oncology, Biology, Physics, vol. 62, no. 3, pp. 652–658, 2005. View at Publisher · View at Google Scholar · View at Scopus
  107. P. Kelly, P. A. Balter, N. Rebueno et al., “Stereotactic body radiation therapy for patients with lung cancer previously treated with thoracic radiation,” International Journal of Radiation Oncology Biology Physics, vol. 78, no. 5, pp. 1387–1393, 2010. View at Publisher · View at Google Scholar · View at Scopus
  108. D. Coon, A. S. Gokhale, S. A. Burton, D. E. Heron, C. Ozhasoglu, and N. Christie, “Fractionated stereotactic body radiation therapy in the treatment of primary, recurrent, and metastatic lung tumors: the role of positron emission tomography/computed tomography-based treatment planning,” Clinical Lung Cancer, vol. 9, no. 4, pp. 217–221, 2008. View at Publisher · View at Google Scholar · View at Scopus
  109. http://www.janes.com/article/44214/us-government-could-more-than-double-industry-s-f-35-affordability-investment.
  110. http://www.journal.forces.gc.ca/vol12/no2/18-wilner-eng.asp.