Assessing Response to Radiation Therapy Treatment of Bone Metastases: Short-Term Followup of Radiation Therapy Treatment of Bone Metastases with Diffusion-Weighted Magnetic Resonance Imaging

Table 2

The table shows for each metastasis the mean ADC and metastasis/muscle SIRs of DW-MRI examinations performed before and after therapy. ADC mean values reached after therapy are also presented as percent variations from corresponding ADC value registered before therapy. Response patterns are discussed in the text.

Patient	DW metastasis/muscle SIR variations and mean ADC changes
	Before therapy			(×10^−5 mm^2/s ± SD)	30 ± 5 days			(×10^−5 mm^2/s ± SD)	60 ± 7 days			( ×10^−5 mm^2/s ± SD)	% ADC increase
		𝑏-value				𝑏-value				𝑏-value
	Low	Medium	High	ADC	Low	Medium	High	ADC	Low	Medium	High	ADC	30 ± 5 days	60 ± 7 days
1	2.29	1.5	0.89	113.56 ± 16.75	3.5	1.65	0.9	131.71 ± 9.27	2.55	1.08	0.46	195.56 ± 10.20	15.9	72.2
2	1.89	1.52	1.08	72.44 ± 12.58	3.44	1.69	0.96	130.08 ± 6.88	3.51	1.45	0.57	172.52 ± 17.24	81	140
3	1.64	1.41	0.91	86.87 ± 16.16	3.24	1.37	0.84	101.51 ± 8.93	2.27	0.94	0.5	165.04 ± 14.30	17.3	90.2
4	5.98	3.35	2.71	115.08 ± 4.10	9.4	3.39	2.15	191.92 ± 10.37	9.66	3.01	2.05	211.00 ± 6.73	66.7	83.3
5	4.08	1.74	1.47	184.00 ± 29.27	3.61	1.65	1.28	201.23 ± 23.45	3.95	1.82	1.04	247.18 ± 19.55	9.3	34.3
6	2.73	1.73	1.22	145.62 ± 13.75	5.17	1.91	0.78	171.47 ± 10.04	4.56	3.3	0.8	184.65 ± 7.34	17.7	26.8
7	2.11	0.37	0.26	104.44 ± 31.15	2.21	0.55	0.22	128.29 ± 17.95	2.2	0.49	0.22	160.19 ± 11.62	22.8	53.4
8	2.02	1.5	0.95	76.54 ± 2.69	1.94	1.12	0.78	130.08 ± 4.44	1.63	1.34	0.97	156.92 ± 3.57	70.5	104.5
9	1.87	0.92	0.45	146.38 ± 7.61	1.17	0.6	0.32	128.46 ± 2.54	1.15	0.56	0.49	89.00 ± 12.59	−12.2	−39.2
10	1.59	0.77	0.38	95.46 ± 11.10	0.8	0.44	0.36	123.50 ± 17.19	0.75	0.41	0.32	196.71 ± 10.60	29.4	106.0
11	1.47	0.77	0.75	112.69 ± 17.21	0.97	0.81	0.51	123.62 ± 11.49	1.81	0.88	0.48	153.34 ± 19.09	9.7	36.1
12	3.09	1.62	1.22	143.38 ± 18.89	2.16	0.88	0.7	176.62 ± 4.27	2.11	0.95	0.51	181.50 ± 11.03	23.2	26.6
13	2.00	1.17	0.87	106.92 ± 15.46	1.53	0.87	0.59	141.00 ± 18.59	1.37	0.9	0.37	150.31 ± 7.98	31.9	40.6
14	1.54	1.29	1.05	122.15 ± 8.42	1.51	1.28	0.62	137.00 ± 9.36	1.07	0.86	0.48	150.37 ± 8.02	12.2	23.1
15	2.64	2.4	1.4	106.89 ± 12.25	1.6	0.88	0.4	165.70 ± 19.16	1.32	0.75	0.23	183.57 ± 14.32	55.0	71.7
Mean	2.46	1.47	1.04	115.49  ±  14.49	2.81	1.27	0.68	145.43  ±  11.59	2.66	1.25	0.53	173.19  ±  11.61	30.0	57.9